Buchumschlag

Antitrypanosomal activities of proteasome inhibitors

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Nkemngu, Njinkeng (VerfasserIn) , Rosenkranz, Vera (VerfasserIn) , Wink, Michael (VerfasserIn) , Steverding, Dietmar (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2002
In: Antimicrobial agents and chemotherapy
Year: 2002, Jahrgang: 46, Heft: 6, Pages: 2038-2040
ISSN:1098-6596
DOI:10.1128/AAC.46.6.2038-2040.2002
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1128/AAC.46.6.2038-2040.2002
Volltext
Verfasserangaben:Joseph Nkemgu-Njinkeng, Vera Rosenkranz, Michael Wink and Dietmar Steverding

MARC

LEADER 00000caa a2200000 c 4500
001 1564100049
003 DE-627
005 20230427142047.0
007 cr uuu---uuuuu
008 171005s2002 xx |||||o 00| ||eng c
024 7 |a 10.1128/AAC.46.6.2038-2040.2002  |2 doi 
035 |a (DE-627)1564100049 
035 |a (DE-576)494100044 
035 |a (DE-599)BSZ494100044 
035 |a (OCoLC)1340980004 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Nkemngu, Njinkeng  |d 1975-  |e VerfasserIn  |0 (DE-588)128797452  |0 (DE-627)380638754  |0 (DE-576)18748239X  |4 aut 
245 1 0 |a Antitrypanosomal activities of proteasome inhibitors  |c Joseph Nkemgu-Njinkeng, Vera Rosenkranz, Michael Wink and Dietmar Steverding 
264 1 |c 2002 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 05.10.2017 
520 |a Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development. 
700 1 |a Rosenkranz, Vera  |e VerfasserIn  |0 (DE-588)1117234215  |0 (DE-627)871322749  |0 (DE-576)478856474  |4 aut 
700 1 |a Wink, Michael  |d 1951-  |e VerfasserIn  |0 (DE-588)124618146  |0 (DE-627)363448519  |0 (DE-576)164659390  |4 aut 
700 1 |a Steverding, Dietmar  |e VerfasserIn  |0 (DE-588)1084824175  |0 (DE-627)848748328  |0 (DE-576)16720761X  |4 aut 
773 0 8 |i Enthalten in  |t Antimicrobial agents and chemotherapy  |d Washington, DC : Soc., 1972  |g 46(2002), 6, Seite 2038-2040  |h Online-Ressource  |w (DE-627)306316919  |w (DE-600)1496156-8  |w (DE-576)09718859X  |x 1098-6596  |7 nnas  |a Antitrypanosomal activities of proteasome inhibitors 
773 1 8 |g volume:46  |g year:2002  |g number:6  |g pages:2038-2040  |g extent:4  |a Antitrypanosomal activities of proteasome inhibitors 
856 4 0 |u http://dx.doi.org/10.1128/AAC.46.6.2038-2040.2002  |x Verlag  |x Resolving-System  |3 Volltext 
951 |a AR 
992 |a 20171005 
993 |a Article 
994 |a 2002 
998 |g 1084824175  |a Steverding, Dietmar  |m 1084824175:Steverding, Dietmar  |d 50000  |e 50000PS1084824175  |k 0/50000/  |p 4  |y j 
998 |g 124618146  |a Wink, Michael  |m 124618146:Wink, Michael  |d 170000  |d 170300  |d 160000  |d 160100  |e 170000PW124618146  |e 170300PW124618146  |e 160000PW124618146  |e 160100PW124618146  |k 0/170000/  |k 1/170000/170300/  |k 0/160000/  |k 1/160000/160100/  |p 3 
998 |g 1117234215  |a Rosenkranz, Vera  |m 1117234215:Rosenkranz, Vera  |d 170000  |d 170300  |d 160000  |d 160100  |e 170000PR1117234215  |e 170300PR1117234215  |e 160000PR1117234215  |e 160100PR1117234215  |k 0/170000/  |k 1/170000/170300/  |k 0/160000/  |k 1/160000/160100/  |p 2 
998 |g 128797452  |a Nkemngu, Njinkeng  |m 128797452:Nkemngu, Njinkeng  |d 910000  |d 911700  |e 910000PN128797452  |e 911700PN128797452  |k 0/910000/  |k 1/910000/911700/  |p 1  |x j 
999 |a KXP-PPN1564100049  |e 2982762641 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1564100049"],"doi":["10.1128/AAC.46.6.2038-2040.2002"]},"recId":"1564100049","relHost":[{"id":{"zdb":["1496156-8"],"eki":["306316919"],"issn":["1098-6596"]},"corporate":[{"role":"isb","display":"American Society for Microbiology","roleDisplay":"Herausgebendes Organ"}],"title":[{"title_sort":"Antimicrobial agents and chemotherapy","subtitle":"AAC","title":"Antimicrobial agents and chemotherapy"}],"titleAlt":[{"title":"AAC"}],"part":{"volume":"46","text":"46(2002), 6, Seite 2038-2040","pages":"2038-2040","year":"2002","extent":"4","issue":"6"},"pubHistory":["1.1972 -"],"disp":"Antitrypanosomal activities of proteasome inhibitorsAntimicrobial agents and chemotherapy","recId":"306316919","note":["Gesehen am 09.06.21"],"language":["eng"],"origin":[{"dateIssuedDisp":"1972-","dateIssuedKey":"1972","publisher":"Soc.","publisherPlace":"Washington, DC"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. by the American Society for Microbiology"]}}],"person":[{"display":"Nkemngu, Njinkeng","role":"aut","given":"Njinkeng","family":"Nkemngu","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Rosenkranz","given":"Vera","role":"aut","display":"Rosenkranz, Vera"},{"display":"Wink, Michael","role":"aut","family":"Wink","given":"Michael","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Steverding","given":"Dietmar","role":"aut","display":"Steverding, Dietmar"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2002","dateIssuedDisp":"2002"}],"language":["eng"],"title":[{"title_sort":"Antitrypanosomal activities of proteasome inhibitors","title":"Antitrypanosomal activities of proteasome inhibitors"}],"note":["Gesehen am 05.10.2017"],"name":{"displayForm":["Joseph Nkemgu-Njinkeng, Vera Rosenkranz, Michael Wink and Dietmar Steverding"]},"physDesc":[{"extent":"4 S."}]} 
SRT |a NKEMNGUNJIANTITRYPAN2002 

Ähnliche Einträge