Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?
This study aimed to explore the ability of a minimal invasive biopsy to diagnose a pathological complete response (pCR = ypT0) in the breast. Ultrasound-guided, vacuum-assisted, minimal invasive biopsy (VAB) was performed in 50 patients after neoadjuvant chemotherapy and before breast surgery. Negat...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 November 2016
|
| In: |
European journal of cancer
Year: 2016, Jahrgang: 69, Pages: 142-150 |
| ISSN: | 1879-0852 |
| DOI: | 10.1016/j.ejca.2016.09.034 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejca.2016.09.034 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0959804916324807 
|
| Verfasserangaben: | Joerg Heil, Benedikt Schaefgen, Peter Sinn, Hannah Richter, Aba Harcos, Christina Gomez, Anne Stieber, André Hennigs, Geraldine Rauch, Florian Schuetz, Christof Sohn, Andreas Schneeweiss, Michael Golatta |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 156411063X | ||
| 003 | DE-627 | ||
| 005 | 20240316100238.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171005s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejca.2016.09.034 |2 doi | |
| 035 | |a (DE-627)156411063X | ||
| 035 | |a (DE-576)494110635 | ||
| 035 | |a (DE-599)BSZ494110635 | ||
| 035 | |a (OCoLC)1340980057 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Heil, Jörg |d 1978- |e VerfasserIn |0 (DE-588)132580187 |0 (DE-627)52396160X |0 (DE-576)299238679 |4 aut | |
| 245 | 1 | 0 | |a Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy? |c Joerg Heil, Benedikt Schaefgen, Peter Sinn, Hannah Richter, Aba Harcos, Christina Gomez, Anne Stieber, André Hennigs, Geraldine Rauch, Florian Schuetz, Christof Sohn, Andreas Schneeweiss, Michael Golatta |
| 264 | 1 | |c 4 November 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.10.2017 | ||
| 520 | |a This study aimed to explore the ability of a minimal invasive biopsy to diagnose a pathological complete response (pCR = ypT0) in the breast. Ultrasound-guided, vacuum-assisted, minimal invasive biopsy (VAB) was performed in 50 patients after neoadjuvant chemotherapy and before breast surgery. Negative predictive values (NPV) and false negative rates (FNR) to predict a pCR in surgical specimen were the main outcome measures. To assess the possible sampling error, the representativeness of the sample was evaluated by the biopsy performing physician (subjectively based on the visibility in ultrasound), by radiography of the biopsy specimen, and by the pathologist (based on histopathology). The cohort (n = 50) consisted of 15 (30%) triple negative breast cancers, 13 (26%) human epidermal growth factor receptor 2 (HER2) positive and 22 (44%) hormone receptor positive/HER2 negative cancers. ypT0 was diagnosed in 23 (46%) cases. In the overall cohort (n = 50), VAB yielded an NPV of 76.7% and an FNR of 25.9%. Given a representative VAB sample, according to the histopathological evaluation (n = 38), the NPV was 94.4% (95% CI 87.1-100.0) and the FNR 4.8% (95% CI 0.0-11.6). Non-representative VABs were mainly due to bad visibility of the target lesion in ultrasound. A VAB can accurately diagnose a pCR, given a histopathologically representative sample. | ||
| 650 | 4 | |a Invasive breast cancer | |
| 650 | 4 | |a Neoadjuvant chemotherapy | |
| 650 | 4 | |a Pathological complete response | |
| 650 | 4 | |a Vacuum-assisted biopsy | |
| 700 | 1 | |a Schäfgen, Benedikt |d 1989- |e VerfasserIn |0 (DE-588)1125143754 |0 (DE-627)879456183 |0 (DE-576)483340790 |4 aut | |
| 700 | 1 | |a Sinn, Peter |d 1957- |e VerfasserIn |0 (DE-588)1022590944 |0 (DE-627)717004783 |0 (DE-576)365646342 |4 aut | |
| 700 | 1 | |a Richter, Hannah |d 1989- |e VerfasserIn |0 (DE-588)1140868683 |0 (DE-627)898741130 |0 (DE-576)494104724 |4 aut | |
| 700 | 1 | |a Harcos, Aba |e VerfasserIn |0 (DE-588)1136396004 |0 (DE-627)892803487 |0 (DE-576)490503594 |4 aut | |
| 700 | 1 | |a Gomez, Christina |e VerfasserIn |0 (DE-588)1140871358 |0 (DE-627)898745012 |0 (DE-576)494108444 |4 aut | |
| 700 | 1 | |a Stieber, Anne |e VerfasserIn |0 (DE-588)111704873X |0 (DE-627)870924613 |0 (DE-576)478697228 |4 aut | |
| 700 | 1 | |a Hennigs, André |e VerfasserIn |0 (DE-588)1077795238 |0 (DE-627)837512395 |0 (DE-576)446682780 |4 aut | |
| 700 | 1 | |a Rauch, Geraldine |e VerfasserIn |0 (DE-588)139823492 |0 (DE-627)61378944X |0 (DE-576)313422923 |4 aut | |
| 700 | 1 | |a Schütz, Florian |d 1972- |e VerfasserIn |0 (DE-588)12303387X |0 (DE-627)082307229 |0 (DE-576)293528810 |4 aut | |
| 700 | 1 | |a Sohn, Christof |d 1961- |e VerfasserIn |0 (DE-588)131349287 |0 (DE-627)507642902 |0 (DE-576)298422255 |4 aut | |
| 700 | 1 | |a Schneeweiss, Andreas |d 1961- |e VerfasserIn |0 (DE-588)109972554 |0 (DE-627)632849630 |0 (DE-576)327251859 |4 aut | |
| 700 | 1 | |a Golatta, Michael |d 1974- |e VerfasserIn |0 (DE-588)132350386 |0 (DE-627)521535727 |0 (DE-576)299091392 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cancer |d Amsterdam [u.a.] : Elsevier, 1992 |g 69(2016), Supplement C, Seite 142-150 |w (DE-627)266883400 |w (DE-600)1468190-0 |w (DE-576)090954173 |x 1879-0852 |7 nnas |a Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy? |
| 773 | 1 | 8 | |g volume:69 |g year:2016 |g supplement:Supplement C |g pages:142-150 |g extent:9 |a Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy? |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ejca.2016.09.034 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0959804916324807 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171005 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 132350386 |a Golatta, Michael |m 132350386:Golatta, Michael |d 910000 |d 910400 |e 910000PG132350386 |e 910400PG132350386 |k 0/910000/ |k 1/910000/910400/ |p 13 |y j | ||
| 998 | |g 109972554 |a Schneeweiss, Andreas |m 109972554:Schneeweiss, Andreas |d 910000 |d 910400 |e 910000PS109972554 |e 910400PS109972554 |k 0/910000/ |k 1/910000/910400/ |p 12 | ||
| 998 | |g 131349287 |a Sohn, Christof |m 131349287:Sohn, Christof |d 910000 |d 910400 |e 910000PS131349287 |e 910400PS131349287 |k 0/910000/ |k 1/910000/910400/ |p 11 | ||
| 998 | |g 12303387X |a Schütz, Florian |m 12303387X:Schütz, Florian |d 910000 |d 910400 |d 50000 |e 910000PS12303387X |e 910400PS12303387X |e 50000PS12303387X |k 0/910000/ |k 1/910000/910400/ |k 0/50000/ |p 10 | ||
| 998 | |g 139823492 |a Rauch, Geraldine |m 139823492:Rauch, Geraldine |d 910000 |d 999701 |d 50000 |e 910000PR139823492 |e 999701PR139823492 |e 50000PR139823492 |k 0/910000/ |k 1/910000/999701/ |k 0/50000/ |p 9 | ||
| 998 | |g 1077795238 |a Hennigs, André |m 1077795238:Hennigs, André |d 910000 |d 910400 |e 910000PH1077795238 |e 910400PH1077795238 |k 0/910000/ |k 1/910000/910400/ |p 8 | ||
| 998 | |g 111704873X |a Stieber, Anne |m 111704873X:Stieber, Anne |d 910000 |d 911400 |e 910000PS111704873X |e 911400PS111704873X |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 1140871358 |a Gomez, Christina |m 1140871358:Gomez, Christina |d 910000 |d 910400 |e 910000PG1140871358 |e 910400PG1140871358 |k 0/910000/ |k 1/910000/910400/ |p 6 | ||
| 998 | |g 1136396004 |a Harcos, Aba |m 1136396004:Harcos, Aba |d 910000 |d 910400 |e 910000PH1136396004 |e 910400PH1136396004 |k 0/910000/ |k 1/910000/910400/ |p 5 | ||
| 998 | |g 1140868683 |a Richter, Hannah |m 1140868683:Richter, Hannah |d 910000 |d 910400 |e 910000PR1140868683 |e 910400PR1140868683 |k 0/910000/ |k 1/910000/910400/ |p 4 | ||
| 998 | |g 1022590944 |a Sinn, Peter |m 1022590944:Sinn, Peter |d 910000 |d 912000 |e 910000PS1022590944 |e 912000PS1022590944 |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 1125143754 |a Schäfgen, Benedikt |m 1125143754:Schäfgen, Benedikt |d 910000 |d 910400 |e 910000PS1125143754 |e 910400PS1125143754 |k 0/910000/ |k 1/910000/910400/ |p 2 | ||
| 998 | |g 132580187 |a Heil, Jörg |m 132580187:Heil, Jörg |d 910000 |d 910400 |e 910000PH132580187 |e 910400PH132580187 |k 0/910000/ |k 1/910000/910400/ |p 1 |x j | ||
| 999 | |a KXP-PPN156411063X |e 2982778181 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Jörg","display":"Heil, Jörg","family":"Heil","role":"aut"},{"role":"aut","family":"Schäfgen","display":"Schäfgen, Benedikt","given":"Benedikt"},{"role":"aut","given":"Peter","display":"Sinn, Peter","family":"Sinn"},{"display":"Richter, Hannah","given":"Hannah","family":"Richter","role":"aut"},{"role":"aut","family":"Harcos","given":"Aba","display":"Harcos, Aba"},{"family":"Gomez","display":"Gomez, Christina","given":"Christina","role":"aut"},{"family":"Stieber","given":"Anne","display":"Stieber, Anne","role":"aut"},{"family":"Hennigs","display":"Hennigs, André","given":"André","role":"aut"},{"role":"aut","given":"Geraldine","display":"Rauch, Geraldine","family":"Rauch"},{"family":"Schütz","given":"Florian","display":"Schütz, Florian","role":"aut"},{"role":"aut","family":"Sohn","given":"Christof","display":"Sohn, Christof"},{"given":"Andreas","display":"Schneeweiss, Andreas","family":"Schneeweiss","role":"aut"},{"family":"Golatta","display":"Golatta, Michael","given":"Michael","role":"aut"}],"recId":"156411063X","origin":[{"dateIssuedDisp":"4 November 2016","dateIssuedKey":"2016"}],"name":{"displayForm":["Joerg Heil, Benedikt Schaefgen, Peter Sinn, Hannah Richter, Aba Harcos, Christina Gomez, Anne Stieber, André Hennigs, Geraldine Rauch, Florian Schuetz, Christof Sohn, Andreas Schneeweiss, Michael Golatta"]},"language":["eng"],"title":[{"title":"Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?","title_sort":"Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?"}],"physDesc":[{"extent":"9 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["156411063X"],"doi":["10.1016/j.ejca.2016.09.034"]},"relHost":[{"pubHistory":["28.1992 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Can a pathological complete response of breast cancer after neoadjuvant chemotherapy be diagnosed by minimal invasive biopsy?European journal of cancer","recId":"266883400","titleAlt":[{"title":"EJC online"}],"language":["eng"],"id":{"zdb":["1468190-0"],"issn":["1879-0852"],"eki":["266883400"]},"part":{"text":"69(2016), Supplement C, Seite 142-150","volume":"69","pages":"142-150","year":"2016","extent":"9"},"note":["Gesehen am 21.03.24","Ungezählte Beil.: Supplement"],"origin":[{"dateIssuedKey":"1992","publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]","publisher":"Elsevier ; Pergamon Press","dateIssuedDisp":"1992-"}],"corporate":[{"display":"European Organization for Research on Treatment of Cancer","role":"isb"},{"display":"European Association for Cancer Research","role":"isb"},{"display":"European School of Oncology","role":"isb"}],"title":[{"title_sort":"European journal of cancer","title":"European journal of cancer"}]}],"note":["Gesehen am 05.10.2017"]} | ||
| SRT | |a HEILJOERGSCANAPATHOL4201 | ||