WISP1 is a novel adipokine linked to inflammation in obesity
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogen...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2015
|
| In: |
Diabetes
Year: 2015, Jahrgang: 64, Heft: 3, Pages: 856-866 |
| ISSN: | 1939-327X |
| DOI: | 10.2337/db14-0444 |
| Online-Zugang: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.2337/db14-0444 Verlag, teilw. kostenfrei, Volltext: http://diabetes.diabetesjournals.org.ezproxy.medma.uni-heidelberg.de/content/64/3/856 
|
| Verfasserangaben: | Veronica Murahovschi, Olga Pivovarova, Iryna Ilkavets, Renata M. Dmitrieva, Stephanie Döcke, Farnaz Keyhani-Nejad, Özlem Gögebakan, Martin Osterhoff, Margrit Kemper, Silke Hornemann, Mariya Markova, Nora Klöting, Martin Stockmann, Martin O. Weickert, Valeria Lamounier-Zepter, Peter Neuhaus, Alexandra Konradi, Steven Dooley, Christian von Loeffelholz, Matthias Blüher, Andreas F.H. Pfeiffer, and Natalia Rudovich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1564138062 | ||
| 003 | DE-627 | ||
| 005 | 20230427142048.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171006s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2337/db14-0444 |2 doi | |
| 035 | |a (DE-627)1564138062 | ||
| 035 | |a (DE-576)494138068 | ||
| 035 | |a (DE-599)BSZ494138068 | ||
| 035 | |a (OCoLC)1340980325 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Murahovschi, Veronica |d 1984- |e VerfasserIn |0 (DE-588)1075737737 |0 (DE-627)833652710 |0 (DE-576)444603131 |4 aut | |
| 245 | 1 | 0 | |a WISP1 is a novel adipokine linked to inflammation in obesity |c Veronica Murahovschi, Olga Pivovarova, Iryna Ilkavets, Renata M. Dmitrieva, Stephanie Döcke, Farnaz Keyhani-Nejad, Özlem Gögebakan, Martin Osterhoff, Margrit Kemper, Silke Hornemann, Mariya Markova, Nora Klöting, Martin Stockmann, Martin O. Weickert, Valeria Lamounier-Zepter, Peter Neuhaus, Alexandra Konradi, Steven Dooley, Christian von Loeffelholz, Matthias Blüher, Andreas F.H. Pfeiffer, and Natalia Rudovich |
| 264 | 1 | |c March 2015 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.10.2017 | ||
| 520 | |a WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade inflammation in obesity. We aimed to validate WISP1 as a novel adipokine. Human adipocyte differentiation was associated with increased WISP1 expression and secretion. Stimulation of human macrophages with WISP1 led to a proinflammatory response. Circulating WISP1 and WISP1 subcutaneous adipose tissue expression were regulated by weight changes in humans and mice. WISP1 expression in visceral and subcutaneous fat tissue was associated with markers of insulin resistance and inflammation in glucose-tolerant subjects. In patients with nonalcoholic fatty liver disease, we found no correlation among disease activity score, liver fat content, and WISP1 expression. Insulin regulated WISP1 expression in adipocytes in vitro but had no acute effect on WISP1 gene expression in subcutaneous fat tissue in overweight subjects who had undergone hyperinsulinemic clamp experiments. The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin resistance and could be a novel therapeutic target for obesity. | ||
| 700 | 1 | |a Dooley, Steven |d 1960- |e VerfasserIn |0 (DE-588)1028589190 |0 (DE-627)73128951X |0 (DE-576)376074116 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diabetes |d Alexandria, Va : Assoc., 1952 |g 64(2015), 3, Seite 856-866 |h Online-Ressource |w (DE-627)30671521X |w (DE-600)1501252-9 |w (DE-576)082437432 |x 1939-327X |7 nnas |a WISP1 is a novel adipokine linked to inflammation in obesity |
| 773 | 1 | 8 | |g volume:64 |g year:2015 |g number:3 |g pages:856-866 |g extent:11 |a WISP1 is a novel adipokine linked to inflammation in obesity |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2337/db14-0444 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://diabetes.diabetesjournals.org.ezproxy.medma.uni-heidelberg.de/content/64/3/856 |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171006 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1028589190 |a Dooley, Steven |m 1028589190:Dooley, Steven |d 60000 |d 61100 |e 60000PD1028589190 |e 61100PD1028589190 |k 0/60000/ |k 1/60000/61100/ |p 18 | ||
| 999 | |a KXP-PPN1564138062 |e 2982853701 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"March 2015","dateIssuedKey":"2015"}],"note":["Gesehen am 06.10.2017"],"recId":"1564138062","name":{"displayForm":["Veronica Murahovschi, Olga Pivovarova, Iryna Ilkavets, Renata M. Dmitrieva, Stephanie Döcke, Farnaz Keyhani-Nejad, Özlem Gögebakan, Martin Osterhoff, Margrit Kemper, Silke Hornemann, Mariya Markova, Nora Klöting, Martin Stockmann, Martin O. Weickert, Valeria Lamounier-Zepter, Peter Neuhaus, Alexandra Konradi, Steven Dooley, Christian von Loeffelholz, Matthias Blüher, Andreas F.H. Pfeiffer, and Natalia Rudovich"]},"title":[{"title":"WISP1 is a novel adipokine linked to inflammation in obesity","title_sort":"WISP1 is a novel adipokine linked to inflammation in obesity"}],"relHost":[{"title":[{"title":"Diabetes","subtitle":"a journal of the American Diabetes Association","title_sort":"Diabetes"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"corporate":[{"role":"isb","display":"American Diabetes Association"}],"disp":"WISP1 is a novel adipokine linked to inflammation in obesityDiabetes","note":["Gesehen am 21.01.2022"],"part":{"text":"64(2015), 3, Seite 856-866","pages":"856-866","issue":"3","year":"2015","extent":"11","volume":"64"},"pubHistory":["1.1952 -"],"id":{"eki":["30671521X"],"zdb":["1501252-9"],"issn":["1939-327X"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"1952","publisherPlace":"Alexandria, Va","publisher":"Assoc.","dateIssuedDisp":"1952-"}],"recId":"30671521X"}],"physDesc":[{"extent":"11 S."}],"id":{"eki":["1564138062"],"doi":["10.2337/db14-0444"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"family":"Murahovschi","given":"Veronica","display":"Murahovschi, Veronica","role":"aut"},{"display":"Dooley, Steven","role":"aut","family":"Dooley","given":"Steven"}]} | ||
| SRT | |a MURAHOVSCHWISP1ISANO2015 | ||