Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

HIV protease (PR) is required for proteolytic maturation in the late phase of HIV replication and represents a prime therapeutic target. The regulation and kinetics of viral polyprotein processing and maturation are currently not understood in detail. Here we design, synthesize, validate and apply a...

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Hauptverfasser:	Schimer, Jiří (VerfasserIn) , Anders-Ößwein, Maria (VerfasserIn) , Kräusslich, Hans-Georg (VerfasserIn) , Müller, Barbara (VerfasserIn)
Dokumenttyp:	Article (Journal)
Sprache:	Englisch
Veröffentlicht:	9 Mar 2015
In:	Nature Communications Year: 2015, Jahrgang: 6
ISSN:	2041-1723
DOI:	10.1038/ncomms7461
Online-Zugang:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms7461 Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366505/
Verfasserangaben:	Jiří Schimer, Marcela Pávová, Maria Anders, Petr Pachl, Pavel Šácha, Petr Cígler, Jan Weber, Pavel Majer, Pavlína Řezáčová, Hans-Georg Kräusslich, Barbara Müller and Jan Konvalinka

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

in: Nature Communications, 6 (2015) Artikel-Nr. 6461, 8 S.

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Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

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