Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets
The objective of this investigation was to characterize the active-component harpagoside of Harpagophytum extract from a physico-chemical perspective and to determine its in-vitro release from tablets according to DAB 1996. It was found that both pure harpagoside and harpagoside in Harpagophytum ext...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2000
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| In: |
Phytomedicine
Year: 2000, Jahrgang: 6, Heft: 6, Pages: 469-473 |
| ISSN: | 1618-095X |
| Online-Zugang: | Verlag, Pay-per-use, Volltext: https://ac.els-cdn.com/S0944711300800768/1-s2.0-S0944711300800768-main.pdf?_tid=e227d9ec-acc1-11e7-bca7-00000aab0f27&acdnat=1507533618_e3a175776c99415e0da75a18515f3e7f
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| Verfasserangaben: | S. Chrubasik, F. Sporer, R. Dillmann-Marschner, A. Friedmann and M. Wink |
MARC
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| 245 | 1 | 0 | |a Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets |c S. Chrubasik, F. Sporer, R. Dillmann-Marschner, A. Friedmann and M. Wink |
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| 520 | |a The objective of this investigation was to characterize the active-component harpagoside of Harpagophytum extract from a physico-chemical perspective and to determine its in-vitro release from tablets according to DAB 1996. It was found that both pure harpagoside and harpagoside in Harpagophytum extract have an octanol-water distribution coefficient of approximately 4 which is neither dependent on temperature nor on pH. The mean harpagoside content in Harpagophytum tablets of Batch 9102 was 16.4 mg (S.D. 0.2; S.E. 0.03). Related to a tablet weight of 365 mg (100%), this corresponds to a haragoside content of 4.5% (S.D. 0.049; S.E. 0.006). On average the tablets disintegrate after 18 +/- 3 minutes (mean +/- SD). The tablets taken from Batch 9102 released the active component harpagoside well, with a t50 of 13.5 min, a t90 of 23 min and a t95 of 25 min in relation to 16.5 mg of harpagoside per dose. Harpagoside content decreased by about 10% in artificial gastric fluid within a period of 3 hours and remained stable in artificial intestinal fluid for a period of 6 hours. | ||
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