L-5-hydroxytryptophan: antioxidant and anti-apoptotic principle of the intertidal sponge Hymeniacidon heliophila
The intertidal sponge Hymeniacidon heliophila which survives under intense sunlight contains the antioxidant amino acid l-5-hydroxytryptophan (ʟ-5-HTP) as major constituent. The content of ʟ-5-HTP was determined as (0.45 ± 0.23)% of the dry weight by quantitative NMR-spectroscopical analysis with an...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
02.06.2014
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| In: |
Zeitschrift für Naturforschung. C, a journal of biosciences
Year: 2003, Jahrgang: 58, Heft: 7/8, Pages: 568-572 |
| ISSN: | 1865-7125 |
| DOI: | 10.1515/znc-2003-7-821 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1515/znc-2003-7-821 Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/view/j/znc.2003.58.issue-7-8/znc-2003-7-821/znc-2003-7-821.xml 
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| Verfasserangaben: | Nicola Lysek, Ralf Kinscherf, Ralf Claus, and Thomas Lindel |
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| 520 | |a The intertidal sponge Hymeniacidon heliophila which survives under intense sunlight contains the antioxidant amino acid l-5-hydroxytryptophan (ʟ-5-HTP) as major constituent. The content of ʟ-5-HTP was determined as (0.45 ± 0.23)% of the dry weight by quantitative NMR-spectroscopical analysis with an internal standard. Other known antioxidants such as flavonoids, carotenoids or tocopherol derivatives were absent. Both the oxidation potential and the concentration of ʟ-5-HTP in H. heliophila correspond to the values observed for flavonoids being major antioxidants in plants. It was shown that ʟ-5-HTP suppresses UVinduced apoptosis in human monocytes at the same concentrations as it occurs in the sponge tissue. | ||
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