Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid
Enhanced levels in tumors of hyaluronan, a glycosaminoglycan component of the extracellular matrix, and hyaluronidases such as hyaluronidase-1 (Hyal1) that degrade hyaluronan have both been linked to poor prognosis and metastasis, suggesting that the turnover of hyaluronan might contribute to tumor...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 March 2015
|
| In: |
Glycobiology
Year: 2015, Jahrgang: 25, Heft: 3, Pages: 258-268 |
| ISSN: | 1460-2423 |
| DOI: | 10.1093/glycob/cwu106 |
| Online-Zugang: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.1093/glycob/cwu106 Verlag, teilw. kostenfrei, Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/glycob/article/25/3/258/2910593/Hyaluronidase-1-expression-promotes-lung 
|
| Verfasserangaben: | Anja Schmaus and Jonathan P. Sleeman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1564618544 | ||
| 003 | DE-627 | ||
| 005 | 20220814005242.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171020s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/glycob/cwu106 |2 doi | |
| 035 | |a (DE-627)1564618544 | ||
| 035 | |a (DE-576)49461854X | ||
| 035 | |a (DE-599)BSZ49461854X | ||
| 035 | |a (OCoLC)1340980774 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmaus, Anja |d 1982- |e VerfasserIn |0 (DE-588)1018776931 |0 (DE-627)68342419X |0 (DE-576)355520613 |4 aut | |
| 245 | 1 | 0 | |a Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid |c Anja Schmaus and Jonathan P. Sleeman |
| 264 | 1 | |c 1 March 2015 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.10.2017 | ||
| 520 | |a Enhanced levels in tumors of hyaluronan, a glycosaminoglycan component of the extracellular matrix, and hyaluronidases such as hyaluronidase-1 (Hyal1) that degrade hyaluronan have both been linked to poor prognosis and metastasis, suggesting that the turnover of hyaluronan might contribute to tumor progression. Small hyaluronan oligosaccharides (sHA) can accumulate in tumor interstitial fluid (TIF), and have been implicated in a number of processes that drive tumor progression, including MMP expression and angiogenesis. The properties of Hyal1 suggest that it might contribute to the degradation of hyaluronan in tumors and the subsequent accumulation of sHA. Accumulation of Hyal1-produced sHA may therefore account for the association between Hyal1 and metastasis. Here we have investigated this hypothesis using mouse syngeneic breast tumor models. Specifically, we modulated Hyal1 expression and activity either in the tumor cells themselves, or in the stromal compartment by using Hyal1 knockout (KO) mice. These approaches did not change sHA levels in TIF, but nevertheless fostered metastasis to the lung in some of the models used in the study. Together, these data suggest that Hyal1 can promote lung metastasis in a manner that is not dependent on altered accumulation of sHA in TIF. | ||
| 700 | 1 | |a Sleeman, Jonathan P. |d 1965- |e VerfasserIn |0 (DE-588)1026079829 |0 (DE-627)726024554 |0 (DE-576)371076722 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Glycobiology |d Oxford : Oxford Univ. Press, 1990 |g 25(2015), 3, Seite 258-268 |h Online-Ressource |w (DE-627)270929703 |w (DE-600)1478140-2 |w (DE-576)082435278 |x 1460-2423 |7 nnas |a Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid |
| 773 | 1 | 8 | |g volume:25 |g year:2015 |g number:3 |g pages:258-268 |g extent:11 |a Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/glycob/cwu106 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/glycob/article/25/3/258/2910593/Hyaluronidase-1-expression-promotes-lung |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171020 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1026079829 |a Sleeman, Jonathan P. |m 1026079829:Sleeman, Jonathan P. |d 60000 |d 999810 |e 60000PS1026079829 |e 999810PS1026079829 |k 0/60000/ |k 1/60000/999810/ |p 2 |y j | ||
| 998 | |g 1018776931 |a Schmaus, Anja |m 1018776931:Schmaus, Anja |d 60000 |d 999810 |e 60000PS1018776931 |e 999810PS1018776931 |k 0/60000/ |k 1/60000/999810/ |p 1 |x j | ||
| 999 | |a KXP-PPN1564618544 |e 2985132835 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid","title_sort":"Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid"}],"person":[{"given":"Anja","family":"Schmaus","role":"aut","display":"Schmaus, Anja","roleDisplay":"VerfasserIn"},{"given":"Jonathan P.","family":"Sleeman","role":"aut","display":"Sleeman, Jonathan P.","roleDisplay":"VerfasserIn"}],"recId":"1564618544","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 20.10.2017"],"id":{"doi":["10.1093/glycob/cwu106"],"eki":["1564618544"]},"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"1 March 2015"}],"name":{"displayForm":["Anja Schmaus and Jonathan P. Sleeman"]},"relHost":[{"pubHistory":["1.1990/91 -"],"part":{"issue":"3","pages":"258-268","year":"2015","extent":"11","text":"25(2015), 3, Seite 258-268","volume":"25"},"titleAlt":[{"title":"Glycobiology online"}],"disp":"Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluidGlycobiology","note":["Gesehen am 04. Juni 2020","Fortsetzung der Druck-Ausgabe"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"270929703","language":["eng"],"title":[{"title":"Glycobiology","title_sort":"Glycobiology"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1990","publisher":"Oxford Univ. Press","dateIssuedDisp":"1990-","publisherPlace":"Oxford"}],"id":{"issn":["1460-2423"],"zdb":["1478140-2"],"eki":["270929703"]}}],"physDesc":[{"extent":"11 S."}]} | ||
| SRT | |a SCHMAUSANJHYALURONID1201 | ||