Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects
Cyclooxygenase (COX)-2 is expressed in macrophages of arteriosclerotic lesions and promotes inflammation. We investigated whether COX-2 is already expressed in peripheral blood mononuclear cells (PBMCs) of subjects possessing risk-related factors, such as in smokers and hyperlipidemics. PBMCs were i...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2005
|
| In: |
Free radical biology and medicine
Year: 2004, Volume: 38, Issue: 2, Pages: 235-242 |
| ISSN: | 1873-4596 |
| DOI: | 10.1016/j.freeradbiomed.2004.10.021 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.freeradbiomed.2004.10.021 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0891584904008433 
|
| Author Notes: | Gabriel A. Bonaterra, Wulf Hildebrandt, Anne Bodens, Roland Sauer, Klaus A. Dugi, Hans-Peter Deigner, Wulf Dröge, Jürgen Metz, Ralf Kinscherf |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1564642593 | ||
| 003 | DE-627 | ||
| 005 | 20230427142057.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171023r20052004xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.freeradbiomed.2004.10.021 |2 doi | |
| 035 | |a (DE-627)1564642593 | ||
| 035 | |a (DE-576)494642599 | ||
| 035 | |a (DE-599)BSZ494642599 | ||
| 035 | |a (OCoLC)1340980740 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bonaterra, Gabriel |e VerfasserIn |0 (DE-588)1120132622 |0 (DE-627)873220714 |0 (DE-576)480136173 |4 aut | |
| 245 | 1 | 0 | |a Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects |c Gabriel A. Bonaterra, Wulf Hildebrandt, Anne Bodens, Roland Sauer, Klaus A. Dugi, Hans-Peter Deigner, Wulf Dröge, Jürgen Metz, Ralf Kinscherf |
| 264 | 1 | |c 2005 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online: 11 November 2004 | ||
| 500 | |a Gesehen am 23.10.2017 | ||
| 520 | |a Cyclooxygenase (COX)-2 is expressed in macrophages of arteriosclerotic lesions and promotes inflammation. We investigated whether COX-2 is already expressed in peripheral blood mononuclear cells (PBMCs) of subjects possessing risk-related factors, such as in smokers and hyperlipidemics. PBMCs were isolated from the venous blood of normolipidemic nonsmokers (NL-NSM; n = 15), normolipidemic smokers (NL-SM; n = 12), hyperlipidemic nonsmokers (HL-NSM; n = 10), and hyperlipidemic smokers (HL-SM; n = 10). RNA from PBMCs was used for RT-PCR. Plasma concentrations of oxidized low-density lipoproteins (oxLDL) were measured by ELISA, those of glutamate and cystine by HPLC. The results show that COX-2 expression in PBMCs was significantly increased in the groups with cardiovascular risk factors (NL-SM, HL-SM, HL-NSM) compared with NL-NSM. COX-2 expression in PBMCs was positively correlated with concentrations of total serum cholesterol, oxLDL, glutamate, or cystine. We suggest that the elevated COX-2 expression indicates a priming of PBMCs as a response to a systemic pro-oxidative and proinflammatory shift in subjects with cardiovascular risk factors, which might also contribute to growth and instability of arteriosclerotic lesions. | ||
| 534 | |c 2004 | ||
| 650 | 4 | |a Free radicals | |
| 650 | 4 | |a Hypercholesterolemia | |
| 650 | 4 | |a Hyperlipoproteinemia | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Smoking | |
| 700 | 1 | |a Hildebrandt, Wulf |e VerfasserIn |0 (DE-588)1106354133 |0 (DE-627)863037712 |0 (DE-576)168313065 |4 aut | |
| 700 | 1 | |a Bodens, Anne |e VerfasserIn |0 (DE-588)1142117936 |0 (DE-627)100116833X |0 (DE-576)494642483 |4 aut | |
| 700 | 1 | |a Sauer, Roland |d 1978- |e VerfasserIn |0 (DE-588)1038723523 |0 (DE-627)766369897 |0 (DE-576)392759454 |4 aut | |
| 700 | 1 | |a Dugi, Klaus A. |e VerfasserIn |0 (DE-588)1079452516 |0 (DE-627)841131805 |0 (DE-576)183223403 |4 aut | |
| 700 | 1 | |a Deigner, Hans-Peter |d 1958- |e VerfasserIn |0 (DE-588)1012570606 |0 (DE-627)699716705 |0 (DE-576)345618505 |4 aut | |
| 700 | 1 | |a Dröge, Wulf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Metz, Jürgen |d 1943- |e VerfasserIn |0 (DE-588)1019940506 |0 (DE-627)691057354 |0 (DE-576)359171109 |4 aut | |
| 700 | 1 | |a Kinscherf, Ralf |e VerfasserIn |0 (DE-588)1084823748 |0 (DE-627)848747925 |0 (DE-576)169729516 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Free radical biology and medicine |d New York, NY [u.a.] : Elsevier, 1987 |g 38(2005), 2, Seite 235-242 |h Online-Ressource |w (DE-627)300898568 |w (DE-600)1483653-1 |w (DE-576)098330233 |x 1873-4596 |7 nnas |a Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects |
| 773 | 1 | 8 | |g volume:38 |g year:2005 |g number:2 |g pages:235-242 |g extent:8 |a Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.freeradbiomed.2004.10.021 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0891584904008433 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171023 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 1084823748 |a Kinscherf, Ralf |m 1084823748:Kinscherf, Ralf |d 50000 |d 53100 |e 50000PK1084823748 |e 53100PK1084823748 |k 0/50000/ |k 1/50000/53100/ |p 9 |y j | ||
| 998 | |g 1019940506 |a Metz, Jürgen |m 1019940506:Metz, Jürgen |d 50000 |d 53100 |e 50000PM1019940506 |e 53100PM1019940506 |k 0/50000/ |k 1/50000/53100/ |p 8 | ||
| 998 | |g 1012570606 |a Deigner, Hans-Peter |m 1012570606:Deigner, Hans-Peter |p 6 | ||
| 998 | |g 1079452516 |a Dugi, Klaus A. |m 1079452516:Dugi, Klaus A. |d 910000 |d 910100 |e 910000PD1079452516 |e 910100PD1079452516 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1038723523 |a Sauer, Roland |m 1038723523:Sauer, Roland |d 50000 |d 53100 |e 50000PS1038723523 |e 53100PS1038723523 |k 0/50000/ |k 1/50000/53100/ |p 4 | ||
| 998 | |g 1142117936 |a Bodens, Anne |m 1142117936:Bodens, Anne |d 50000 |d 53100 |e 50000PB1142117936 |e 53100PB1142117936 |k 0/50000/ |k 1/50000/53100/ |p 3 | ||
| 998 | |g 1106354133 |a Hildebrandt, Wulf |m 1106354133:Hildebrandt, Wulf |p 2 | ||
| 998 | |g 1120132622 |a Bonaterra, Gabriel |m 1120132622:Bonaterra, Gabriel |d 50000 |d 53100 |e 50000PB1120132622 |e 53100PB1120132622 |k 0/50000/ |k 1/50000/53100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1564642593 |e 2985647770 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1016/j.freeradbiomed.2004.10.021"],"eki":["1564642593"]},"origin":[{"dateIssuedKey":"2005","dateIssuedDisp":"2005"}],"name":{"displayForm":["Gabriel A. Bonaterra, Wulf Hildebrandt, Anne Bodens, Roland Sauer, Klaus A. Dugi, Hans-Peter Deigner, Wulf Dröge, Jürgen Metz, Ralf Kinscherf"]},"relHost":[{"recId":"300898568","language":["eng"],"disp":"Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjectsFree radical biology and medicine","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Ungezählte Beil.: Supplement"],"titleAlt":[{"title":"Free radical biology & medicine"}],"part":{"extent":"8","text":"38(2005), 2, Seite 235-242","volume":"38","issue":"2","pages":"235-242","year":"2005"},"pubHistory":["3.1987 -"],"title":[{"title":"Free radical biology and medicine","subtitle":"the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research","title_sort":"Free radical biology and medicine"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["300898568"],"zdb":["1483653-1"],"issn":["1873-4596"]},"origin":[{"dateIssuedDisp":"1987-","dateIssuedKey":"1987","publisher":"Elsevier","publisherPlace":"New York, NY [u.a.]"}]}],"physDesc":[{"extent":"8 S."}],"title":[{"title":"Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects","title_sort":"Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects"}],"person":[{"roleDisplay":"VerfasserIn","display":"Bonaterra, Gabriel","role":"aut","family":"Bonaterra","given":"Gabriel"},{"family":"Hildebrandt","given":"Wulf","roleDisplay":"VerfasserIn","display":"Hildebrandt, Wulf","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Bodens, Anne","role":"aut","family":"Bodens","given":"Anne"},{"given":"Roland","family":"Sauer","role":"aut","display":"Sauer, Roland","roleDisplay":"VerfasserIn"},{"display":"Dugi, Klaus A.","roleDisplay":"VerfasserIn","role":"aut","family":"Dugi","given":"Klaus A."},{"given":"Hans-Peter","family":"Deigner","role":"aut","roleDisplay":"VerfasserIn","display":"Deigner, Hans-Peter"},{"role":"aut","display":"Dröge, Wulf","roleDisplay":"VerfasserIn","given":"Wulf","family":"Dröge"},{"given":"Jürgen","family":"Metz","role":"aut","display":"Metz, Jürgen","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Kinscherf, Ralf","role":"aut","family":"Kinscherf","given":"Ralf"}],"recId":"1564642593","language":["eng"],"note":["Available online: 11 November 2004","Gesehen am 23.10.2017"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a BONATERRAGINCREASEDC2005 | ||