23Na-MRI of recurrent glioblastoma multiforme after intraoperative radiotherapy: technical note
Introduction: We report the first case of an intraoperative radiotherapy (IORT) in a patient with recurrent glioblastoma multiforme (GBM) who was followed up with a novel magnetic resonance imaging (MRI) method - 23Na-MRI - in comparison to a standard contrast-enhanced 1H-MRI and 18F-FET-PET. Method...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 November 2014
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| In: |
Neuroradiology
Year: 2014, Volume: 57, Issue: 3, Pages: 321-326 |
| ISSN: | 1432-1920 |
| DOI: | 10.1007/s00234-014-1468-2 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00234-014-1468-2 Verlag, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00234-014-1468-2 
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| Author Notes: | Stefan Haneder, Frank A. Giordano, Simon Konstandin, Stefanie Brehmer, Karen A. Buesing, Peter Schmiedek, Lothar R. Schad, Frederik Wenz, Stefan O. Schoenberg, Melissa M. Ong |
| Summary: | Introduction: We report the first case of an intraoperative radiotherapy (IORT) in a patient with recurrent glioblastoma multiforme (GBM) who was followed up with a novel magnetic resonance imaging (MRI) method - 23Na-MRI - in comparison to a standard contrast-enhanced 1H-MRI and 18F-FET-PET. Methods: A 56-year-old female patient with diagnosed GBM in July 2012 underwent tumor resection, radiochemotherapy, and three cycles of chemotherapy. After a relapse, 6 months after the initial diagnosis, an IORT was recommended which was performed in March 2013 using the INTRABEAM system (Carl Zeiss Meditec AG, Germany) with a 3-cm applicator and a surface dose of 20 Gy. Early post-operative contrast-enhanced and 1-month follow-up 1H-MRI and a 18F-FET-PET were performed. In addition, an IRB-approved 23Na-MRI was performed on a 3.0-T MR scanner (MAGNETOM TimTrio, Siemens Healthcare, Germany). Results: After re-surgery and IORT in March 2013, only a faint contrast enhancement but considerable surrounding edema was visible at the medio-posterior resection margins. In April 2013, new and progressive contrast enhancement, edema, 23Na content, and increased uptake in the 18F-FET-PET were visible, indicating tumor recurrence. Increased sodium content within the area of contrast enhancement was found in the 23Na-MRI, but also exceeding this area, very similar to the increased uptake depicted in the 18F-FET-PET. The clearly delineable zone of edema in both examinations exhibits a lower 23Na content compared to areas with suspected proliferating tumor tissue. Conclusion: 23Na-MRI provided similar information in the suspicious area compared to 18F-FET-PET, exceeding conventional 1H-MRI. Still, 23Na-MRI remains an investigational technique, which is worth to be further evaluated. |
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| Item Description: | Gesehen am 02.11.2017 Im Titel ist „23” hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1432-1920 |
| DOI: | 10.1007/s00234-014-1468-2 |