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Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex

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Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same time the principal pathway for mitochondrial turnove...

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Main Authors: Ebrahimi-Fakhari, Darius (Author) , Saffari, Afshin (Author) , Wahlster, Lara (Author) , Kölker, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 25 October 2016
In: Cell reports
Year: 2016, Volume: 17, Issue: 4, Pages: 1053-1070
ISSN:2211-1247
DOI:10.1016/j.celrep.2016.09.054
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.celrep.2016.09.054
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078873/
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Author Notes:Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis, Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
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Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex by Ebrahimi-Fakhari, Darius (Author) , Saffari, Afshin (Author) , Wahlster, Lara (Author) , Di Nardo, Alessia (Author) , Turner, Daria (Author) , Lewis, Tommy L. (Author) , Conrad, Christopher (Author) , Rothberg, Jonathan M. (Author) , Lipton, Jonathan O. (Author) , Kölker, Stefan (Author) , Hoffmann, Georg F. (Author) , Han, Min-Joon (Author) , Polleux, Franck (Author) , Sahin, Mustafa (Author) ,


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