Prevalence and clinical associations of PTEN loss in non-small cell lung carcinoma (NSCLC) patients (pts) of the European thoracic oncology platform (ETOP) lungscape cohort
© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.Background: Loss of PTEN might be a prognostic biomarker in NSCLC.Methods: We explored the prevalence of PTE...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 October 2016
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| In: |
Annals of oncology
Year: 2016, Jahrgang: 27 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdw392.07 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1093/annonc/mdw392.07 Verlag, kostenfrei, Volltext: https://academic.oup.com/annonc/article/27/suppl_6/1525P/2800422 
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| Verfasserangaben: | A. Soltermann, U. Rulle, O. Dafni, E. Verbeken, E. Thunnissen, A. Warth, R. Cheney, A. Sejda, E.-J. Speel, L. Bille Madsen, D. Nonaka, A. Navarro, I. Sansano, A. Marchetti, S. Finn, R. Kammler, K. Schulze, L. Bubendorf, R.A. Stahel, O.B.O. Lungscape |
| Zusammenfassung: | © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.Background: Loss of PTEN might be a prognostic biomarker in NSCLC.Methods: We explored the prevalence of PTEN loss and its association with clinico-pathologic parameters as well as patient outcome (overall survival (OS), relapse-free survival (RFS) and time to relapse (TTR)) in the ETOP Lungscape cohort of resected stages I-III NSCLC. Tumor tissue was assessed for PTEN protein expression using immunohistochemistry on tissue microarrays. All cases were locally H-scored by ETOP pathologists, after having passed a stringent External Quality Assessment, and were centrally analyzed with pixel-based Image-J computer analysis. PTEN loss was defined as H-score = 0.Results: PTEN expression in tumor tissue was evaluable in 2245 pts from 16 ETOP Lungscape centers with the following characteristics: median follow-up 4.8 years; 54.3% of pts... |
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| Beschreibung: | Gesehen am 10.11.2016 |
| Beschreibung: | Online Resource |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdw392.07 |