Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom
Purpose: Combined radiochemotherapy (RCT) for gastric cancer with three-dimensional conformal radiotherapy (3D-CRT) results in ablative doses to the upper left kidney, while image-guided intensity-modulated radiotherapy (IG-IMRT) allows kidney sparing despite improved target coverage. Renal function...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 December 2014
|
| In: |
Strahlentherapie und Onkologie
Year: 2014, Jahrgang: 191, Heft: 4, Pages: 356-364 |
| ISSN: | 1439-099X |
| DOI: | 10.1007/s00066-014-0787-x |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00066-014-0787-x Verlag, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00066-014-0787-x 
|
| Verfasserangaben: | Stefan Haneder, Johannes Michael Budjan, Stefan Oswald Schoenberg, Simon Konstandin, Lothar Rudi Schad, Ralf Dieter Hofheinz, Veronika Gramlich, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1565464826 | ||
| 003 | DE-627 | ||
| 005 | 20220814024111.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171117r20152014xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00066-014-0787-x |2 doi | |
| 035 | |a (DE-627)1565464826 | ||
| 035 | |a (DE-576)495464821 | ||
| 035 | |a (DE-599)BSZ495464821 | ||
| 035 | |a (OCoLC)1340982241 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Haneder, Stefan |d 1981- |e VerfasserIn |0 (DE-588)136678335 |0 (DE-627)585462097 |0 (DE-576)287960943 |4 aut | |
| 245 | 1 | 0 | |a Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer |b = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom |c Stefan Haneder, Johannes Michael Budjan, Stefan Oswald Schoenberg, Simon Konstandin, Lothar Rudi Schad, Ralf Dieter Hofheinz, Veronika Gramlich, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann |
| 246 | 3 | 1 | |a Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom |
| 246 | 3 | 3 | |a Dose-dependent changes in renal 1 H-/23 Na MRI after adjuvant radiochemotherapy for gastric cancer |
| 264 | 1 | |c 2 December 2014 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.11.2017 | ||
| 500 | |a Im Titel sind „1” und "23" hochgestellt | ||
| 520 | |a Purpose: Combined radiochemotherapy (RCT) for gastric cancer with three-dimensional conformal radiotherapy (3D-CRT) results in ablative doses to the upper left kidney, while image-guided intensity-modulated radiotherapy (IG-IMRT) allows kidney sparing despite improved target coverage. Renal function in long-term gastric cancer survivors was evaluated with 3T functional magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) and 23Na imaging. Patients and methods: Five healthy volunteers and 13 patients after radiotherapy were included: 11×IG-IMRT; 1×3D-CRT; 1× “positive control” with stereotactic body radiotherapy (SBRT) of a metastasis between the spleen/left kidney. Radiation doses were documented for the upper/middle/lower kidney subvolumes. Late toxicity was evaluated based on CTC criteria, questionnaire, and creatinine values. Morphological sequences, DWI images, and 23Na images were acquired using a 1H/23Na-tuned body-coil before/after intravenous water load (WL). Statistics for [23Na] (concentration) and apparent diffusion coefficient (ADC) values were calculated for upper/middle/lower renal subvolumes. Corticomedullary [23Na] gradients and [23Na] differences after WL were determined. Results: No major morphological alteration was detected in any patient. Minor scars were observed in the cranial subvolume of the left kidney of the 3D-CRT and the whole kidney of the control SBRT patient. All participants presented a corticomedullary [23Na] gradient. After WL, a significant physiological [23Na] gradient decrease (p < 0.001) was observed in all HV and IG-IMRT patients. In the cranial left kidney of the 3D-CRT patient and the positive control SBRT patient, the decrease was nonsignificant (p = 0.01, p = 0.02). ADC values were altered nonsignificantly in all renal subvolumes (all participants). Renal subvolumes with doses ≥ 35 Gy showed a reduced change of the [23Na] gradient after WL (p = 0.043). No participants showed clinical renal impairment. Conclusions: Functional parameters of renal 23Na MRI after gastric IG-IMRT are identical to those of healthy volunteers, in contrast to renal subvolumes after ablative doses in the control and 3D-CRT patient. While kidney doses to the cortex below 20-25 Gy in fractional doses of ~ 1 Gy in IG-IMRT (combined with intensified chemotherapy) do not seem to cause significant MRI morphological or functional alterations, doses of > 35 Gy in 1.5-2 Gy fractions clearly result in impairment. | ||
| 534 | |c 2014 | ||
| 700 | 1 | |a Budjan, Johannes |d 1984- |e VerfasserIn |0 (DE-588)1020241047 |0 (DE-627)691154244 |0 (DE-576)359777821 |4 aut | |
| 700 | 1 | |a Schönberg, Stefan |d 1969- |e VerfasserIn |0 (DE-588)131557912 |0 (DE-627)510700624 |0 (DE-576)298584891 |4 aut | |
| 700 | 1 | |a Schad, Lothar R. |d 1956- |e VerfasserIn |0 (DE-588)1028817630 |0 (DE-627)731640241 |0 (DE-576)376271221 |4 aut | |
| 700 | 1 | |a Hofheinz, Ralf-Dieter |d 1969- |e VerfasserIn |0 (DE-588)121917517 |0 (DE-627)08161876X |0 (DE-576)292991568 |4 aut | |
| 700 | 1 | |a Wenz, Frederik |d 1966- |e VerfasserIn |0 (DE-588)113310390 |0 (DE-627)663837766 |0 (DE-576)346656281 |4 aut | |
| 700 | 1 | |a Boda-Heggemann, Judit |d 1977- |e VerfasserIn |0 (DE-588)1029853436 |0 (DE-627)734363087 |0 (DE-576)377699411 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Strahlentherapie und Onkologie |d Berlin : Springer Medizin, 1997 |g 191(2015), 4, Seite 356-364 |h Online-Ressource |w (DE-627)312407866 |w (DE-600)2003907-4 |w (DE-576)090884809 |x 1439-099X |7 nnas |a Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom |
| 773 | 1 | 8 | |g volume:191 |g year:2015 |g number:4 |g pages:356-364 |g extent:9 |a Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00066-014-0787-x |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00066-014-0787-x |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171117 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1029853436 |a Boda-Heggemann, Judit |m 1029853436:Boda-Heggemann, Judit |d 60000 |d 63000 |e 60000PB1029853436 |e 63000PB1029853436 |k 0/60000/ |k 1/60000/63000/ |p 10 |y j | ||
| 998 | |g 113310390 |a Wenz, Frederik |m 113310390:Wenz, Frederik |d 60000 |d 63000 |e 60000PW113310390 |e 63000PW113310390 |k 0/60000/ |k 1/60000/63000/ |p 8 | ||
| 998 | |g 121917517 |a Hofheinz, Ralf-Dieter |m 121917517:Hofheinz, Ralf-Dieter |d 60000 |d 61200 |e 60000PH121917517 |e 61200PH121917517 |k 0/60000/ |k 1/60000/61200/ |p 6 | ||
| 998 | |g 1028817630 |a Schad, Lothar R. |m 1028817630:Schad, Lothar R. |p 5 | ||
| 998 | |g 131557912 |a Schönberg, Stefan |m 131557912:Schönberg, Stefan |d 60000 |d 62900 |e 60000PS131557912 |e 62900PS131557912 |k 0/60000/ |k 1/60000/62900/ |p 3 | ||
| 998 | |g 1020241047 |a Budjan, Johannes |m 1020241047:Budjan, Johannes |d 60000 |d 62900 |e 60000PB1020241047 |e 62900PB1020241047 |k 0/60000/ |k 1/60000/62900/ |p 2 | ||
| 998 | |g 136678335 |a Haneder, Stefan |m 136678335:Haneder, Stefan |d 60000 |d 62900 |e 60000PH136678335 |e 62900PH136678335 |k 0/60000/ |k 1/60000/62900/ |p 1 |x j | ||
| 999 | |a KXP-PPN1565464826 |e 2987419643 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1565464826","language":["eng"],"titleAlt":[{"title":"Dose-dependent changes in renal 1 H-/23 Na MRI after adjuvant radiochemotherapy for gastric cancer"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","family":"Haneder","given":"Stefan","display":"Haneder, Stefan"},{"role":"aut","family":"Budjan","given":"Johannes","display":"Budjan, Johannes"},{"display":"Schönberg, Stefan","given":"Stefan","family":"Schönberg","role":"aut"},{"role":"aut","display":"Schad, Lothar R.","given":"Lothar R.","family":"Schad"},{"given":"Ralf-Dieter","display":"Hofheinz, Ralf-Dieter","family":"Hofheinz","role":"aut"},{"role":"aut","display":"Wenz, Frederik","given":"Frederik","family":"Wenz"},{"role":"aut","display":"Boda-Heggemann, Judit","given":"Judit","family":"Boda-Heggemann"}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"2 December 2014"}],"name":{"displayForm":["Stefan Haneder, Johannes Michael Budjan, Stefan Oswald Schoenberg, Simon Konstandin, Lothar Rudi Schad, Ralf Dieter Hofheinz, Veronika Gramlich, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann"]},"titleTranslated":[{"translated":"Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom"}],"title":[{"title":"Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer","title_sort":"Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer","subtitle":" = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim Magenkarzinom"}],"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1007/s00066-014-0787-x"],"eki":["1565464826"]},"note":["Gesehen am 17.11.2017","Im Titel sind „1” und \"23\" hochgestellt"],"relHost":[{"origin":[{"publisherPlace":"Berlin ; Heidelberg ; [München]","dateIssuedKey":"1997","dateIssuedDisp":"1997-","publisher":"Springer Medizin ; Urban & Vogel"}],"title":[{"title_sort":"Strahlentherapie und Onkologie","subtitle":"journal of radiation oncology, biology, physics","title":"Strahlentherapie und Onkologie"}],"id":{"issn":["1439-099X"],"zdb":["2003907-4"],"eki":["312407866"]},"part":{"volume":"191","text":"191(2015), 4, Seite 356-364","pages":"356-364","year":"2015","issue":"4","extent":"9"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 13.05.09"],"recId":"312407866","disp":"Dose-dependent changes in renal 1H-/23Na MRI after adjuvant radiochemotherapy for gastric cancer = Dosisabhängige Veränderungen im 1H-/23Na-MRT der Niere nach adjuvanter Radiochemotherapie beim MagenkarzinomStrahlentherapie und Onkologie","language":["ger"],"pubHistory":["Nachgewiesen 173.1997 -"],"type":{"bibl":"periodical","media":"Online-Ressource"}}]} | ||
| SRT | |a HANEDERSTEDOSEDEPEND2201 | ||