Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

<p>Whole-genome sequencing identified recurrent fusions involving the <i>MET</i> oncogene, and MET inhibitors suppressed tumor growth in mouse models and in a human patient.</p>

Saved in:

Bibliographic Details
Main Authors:	Bender, Sebastian (Author) , Pfaff, Elke (Author) , Sturm, Dominik (Author) , Jones, Barbara Christine (Author) , Tilburg, Cornelis M. van (Author) , Milford, David (Author) , Heiland, Sabine (Author) , Kalle, Christof von (Author) , Kulozik, Andreas (Author) , Unterberg, Andreas (Author) , Witt, Olaf (Author) , Deimling, Andreas von (Author) , Capper, David (Author) , Brors, Benedikt (Author) , Herold-Mende, Christel (Author) , Korshunov, Andrey (Author) , Eils, Roland (Author) , Pfister, Stefan (Author)
Format:	Article (Journal)
Language:	English
Published:	17 October 2016
In:	Nature medicine Year: 2016, Volume: 22, Issue: 11, Pages: 1314-1322
ISSN:	1546-170X
DOI:	10.1038/nm.4204
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1038/nm.4204 Verlag, Volltext: https://www.nature.com/articles/nm.4204
Author Notes:	Sebastian Bender, Jan Gronych, Hans-Jörg Warnatz, Barbara Hutter, Susanne Gröbner, Marina Ryzhova, Elke Pfaff, Volker Hovestadt, Florian Weinberg, Sebastian Halbach, Marcel Kool, Paul A. Northcott, Dominik Sturm, Lynn Bjerke, Thomas Zichner, Adrian M. Stütz, Kathrin Schramm, Bingding Huang, Ivo Buchhalter, Michael Heinold, Thomas Risch, Barbara C. Worst, Cornelis M. van Tilburg, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, David Milford, Sabine Heiland, Christof von Kalle, Christopher Previti, Chris Lawerenz, Andreas E. Kulozik, Andreas Unterberg, Olaf Witt, Andreas von Deimling, David Capper, Nathalène Truffaux, Jacques Grill, Nada Jabado, Astrid M. Sehested, David Sumerauer, Dorra Hmida-Ben Brahim, Saoussen Trabelsi, Ho-Keung Ng, David Zagzag, Jeffrey C. Allen, Matthias A. Karajannis, Nicholas G. Gottardo, Chris Jones, Jan O. Korbel, Sabine Schmidt, Stephan Wolf, Guido Reifenberger, Jörg Felsberg, Benedikt Brors, Christel Herold-Mende, Hans Lehrach, Tilman Brummer, Andrey Korshunov, Roland Eils, Marie-Laure Yaspo, Stefan M. Pfister, Peter Lichter and David T. W. Jones, for the International Cancer Genome Consortium PedBrain Tumor Project

Description
Summary:	<p>Whole-genome sequencing identified recurrent fusions involving the <i>MET</i> oncogene, and MET inhibitors suppressed tumor growth in mouse models and in a human patient.</p>
Item Description:	Gesehen am 17.11.2017
Physical Description:	Online Resource
ISSN:	1546-170X
DOI:	10.1038/nm.4204