Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
<p>Whole-genome sequencing identified recurrent fusions involving the <i>MET</i> oncogene, and MET inhibitors suppressed tumor growth in mouse models and in a human patient.</p>
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 October 2016
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| In: |
Nature medicine
Year: 2016, Jahrgang: 22, Heft: 11, Pages: 1314-1322 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.4204 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/nm.4204 Verlag, Volltext: https://www.nature.com/articles/nm.4204 
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| Verfasserangaben: | Sebastian Bender, Jan Gronych, Hans-Jörg Warnatz, Barbara Hutter, Susanne Gröbner, Marina Ryzhova, Elke Pfaff, Volker Hovestadt, Florian Weinberg, Sebastian Halbach, Marcel Kool, Paul A. Northcott, Dominik Sturm, Lynn Bjerke, Thomas Zichner, Adrian M. Stütz, Kathrin Schramm, Bingding Huang, Ivo Buchhalter, Michael Heinold, Thomas Risch, Barbara C. Worst, Cornelis M. van Tilburg, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, David Milford, Sabine Heiland, Christof von Kalle, Christopher Previti, Chris Lawerenz, Andreas E. Kulozik, Andreas Unterberg, Olaf Witt, Andreas von Deimling, David Capper, Nathalène Truffaux, Jacques Grill, Nada Jabado, Astrid M. Sehested, David Sumerauer, Dorra Hmida-Ben Brahim, Saoussen Trabelsi, Ho-Keung Ng, David Zagzag, Jeffrey C. Allen, Matthias A. Karajannis, Nicholas G. Gottardo, Chris Jones, Jan O. Korbel, Sabine Schmidt, Stephan Wolf, Guido Reifenberger, Jörg Felsberg, Benedikt Brors, Christel Herold-Mende, Hans Lehrach, Tilman Brummer, Andrey Korshunov, Roland Eils, Marie-Laure Yaspo, Stefan M. Pfister, Peter Lichter and David T. W. Jones, for the International Cancer Genome Consortium PedBrain Tumor Project |
MARC
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