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UV radiation induces CXCL5 expression in human skin

CXCL5 has recently been identified as a mediator of UVB-induced pain in rodents. To compare and to extend previous knowledge of cutaneous CXCL5 regulation, we performed a comprehensive study on the effects of UV radiation on CXCL5 regulation in human skin. Our results show a dose-dependent increase...

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Bibliographische Detailangaben
Hauptverfasser: Reichert, Olga (VerfasserIn) , Schmelz, Martin (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: April 2015
In: Experimental dermatology
Year: 2015, Jahrgang: 24, Heft: 4, Pages: 309-312
ISSN:1600-0625
DOI:10.1111/exd.12652
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1111/exd.12652
Verlag, Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1111/exd.12652/abstract
Volltext
Verfasserangaben:Olga Reichert, Ludger Kolbe, Lara Terstegen, Franz Staeb, Horst Wenck, Martin Schmelz, Harald Genth, Volkhard Kaever, Dennis Roggenkamp and Gitta Neufang

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520 |a CXCL5 has recently been identified as a mediator of UVB-induced pain in rodents. To compare and to extend previous knowledge of cutaneous CXCL5 regulation, we performed a comprehensive study on the effects of UV radiation on CXCL5 regulation in human skin. Our results show a dose-dependent increase in CXCL5 protein in human skin after UV radiation. CXCL5 can be released by different cell types in the skin. We presumed that, in addition to immune cells, non-immune skin cells also contribute to UV-induced increase in CXCL5 protein. Analysis of monocultured dermal fibroblasts and keratinocytes revealed that only fibroblasts but not keratinocytes displayed up regulated CXCL5 levels after UV stimulation. Whereas UV treatment of human skin equivalents, induced epidermal CXCL5 mRNA and protein expression. Up regulation of epidermal CXCL5 was independent of keratinocyte differentiation and keratinocyte-keratinocyte interactions in epidermal layers. Our findings provide first evidence on the release of CXCL5 in UV-radiated human skin and the essential role of fibroblast-keratinocyte interaction in the regulation of epidermal CXCL5. 
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