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Cerebellar vermis area in schizophrenic patients: a post-mortem study

Neuroimaging studies of cerebellar atrophy in schizophrenia have yielded contradictory results. In computer-tomography (CT) studies, cerebellar atrophy was found in up to 40% of schizophrenic patients. However, several recent magnetic resonance imaging (MRI) studies could not replicate these early f...

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Hauptverfasser: Supprian, Tillmann (VerfasserIn) , Ulmar, Gerd (VerfasserIn) , Bauer, Manfred (VerfasserIn) , Schüler, Michael M. (VerfasserIn) , Püschel, Klaus (VerfasserIn) , Retz-Junginger, Petra (VerfasserIn) , Schmitt, Horst Peter (VerfasserIn) , Heinsen, Helmut (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 March 2000
In: Schizophrenia research
Year: 2000, Jahrgang: 42, Heft: 1, Pages: 19-28
ISSN:1573-2509
DOI:10.1016/S0920-9964(99)00103-6
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/S0920-9964(99)00103-6
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0920996499001036
Volltext
Verfasserangaben:Tillmann Supprian, Gerd Ulmar, Manfred Bauer, Michael Schüler, Klaus Püschel, Petra Retz-Junginger, Horst Peter Schmitt, Helmut Heinsen
Beschreibung
Zusammenfassung:Neuroimaging studies of cerebellar atrophy in schizophrenia have yielded contradictory results. In computer-tomography (CT) studies, cerebellar atrophy was found in up to 40% of schizophrenic patients. However, several recent magnetic resonance imaging (MRI) studies could not replicate these early findings; in addition, contradictory observations of enlargement of vermal structures were reported. In contrast to the number of CT and MRI studies, there are only a few neuropathological reports on this subject. In a post-mortem study we analyzed the midsagittal vermal area of formaldehyde-fixed cerebella of 12 deceased schizophrenic patients and 12 age- and gender-matched control subjects by using morphometrical methods. Statistical analysis using ANOVA revealed no significant group effects, but there were interactions with gender and cerebellar brain weight. In view of the present results, the common concept of cerebellar atrophy in schizophrenic patients appears premature. Gender effects and secondary processes (e.g., relevant alcohol or drug abuse) cannot be excluded as possible factors causing decrease of vermal areas in schizophrenic patients.
Beschreibung:Gesehen am 27.11.2017
Beschreibung:Online Resource
ISSN:1573-2509
DOI:10.1016/S0920-9964(99)00103-6

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