Comparison of livestock-associated and health care-associated MRSA: genes, virulence, and resistance
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 August 2016
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| In: |
Diagnostic microbiology and infectious disease
Year: 2016, Volume: 86, Issue: 4, Pages: 417-421 |
| ISSN: | 1879-0070 |
| DOI: | 10.1016/j.diagmicrobio.2016.08.016 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.016 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0732889316302553 
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| Author Notes: | Nico T. Mutters, Christian P. Bieber, Catherine Hauck, Gerald Reiner, Veronika Malek, Uwe Frank |
MARC
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| 520 | |a Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S. aureus (HA-MRSA) and assessed carriage rates. Samples from pigs (n=330), occupationally exposed personnel (n=63), the farm environment (n=134), and hospital patients (n=220) were obtained. Approximately 50% (166/330) of pigs were MRSA positive. All LA-MRSA were resistant to tetracycline, compared to only 8% of HA-MRSA (P<0.001). In contrast, HA-MRSA isolates showed significantly higher resistance rates to quinolones (81% versus 7%; P<0.001). All strains isolated from occupationally exposed personnel (61.9%; 39/63) belonged to CC398. HA-MRSA isolates were diversely distributed, with predominance of CC5 (62.7%). Human strains carried significantly more virulence genes than porcine strains, especially exotoxins (P<0.001) and immune-evasion cluster genes (P<0.001). There were significant differences in resistance patterns and recognized genotypic virulence loci between LA-MRSA and HA-MRSA. | ||
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