Measuring non-vitamin K antagonist oral anticoagulant levels: When is it appropriate and which methods should be used?
BackgroundAlthough the need for an emergency intervention may merit laboratory measurement of non-vitamin K antagonist oral anticoagulant (NOAC) concentration or anticoagulant activity, NOACs are not supposed to require routine monitoring due to their stable pharmacological profiles compared with wa...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 July 2016
|
| In: |
International journal of stroke
Year: 2016, Jahrgang: 11, Heft: 7, Pages: 748-758 |
| ISSN: | 1747-4949 |
| DOI: | 10.1177/1747493016659671 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1177/1747493016659671 Verlag, Volltext: https://doi.org/10.1177/1747493016659671 
|
| Verfasserangaben: | Ludovic Drouet, Claire Bal dit Sollier, Thorsten Steiner and Jan Purrucker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1566090474 | ||
| 003 | DE-627 | ||
| 005 | 20230426064415.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171206s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/1747493016659671 |2 doi | |
| 035 | |a (DE-627)1566090474 | ||
| 035 | |a (DE-576)49609047X | ||
| 035 | |a (DE-599)BSZ49609047X | ||
| 035 | |a (OCoLC)1340983063 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Drouet, Ludovic |e VerfasserIn |0 (DE-588)1147889910 |0 (DE-627)1007283440 |0 (DE-576)49608917X |4 aut | |
| 245 | 1 | 0 | |a Measuring non-vitamin K antagonist oral anticoagulant levels |b When is it appropriate and which methods should be used? |c Ludovic Drouet, Claire Bal dit Sollier, Thorsten Steiner and Jan Purrucker |
| 264 | 1 | |c 13 July 2016 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.12.2017 | ||
| 520 | |a BackgroundAlthough the need for an emergency intervention may merit laboratory measurement of non-vitamin K antagonist oral anticoagulant (NOAC) concentration or anticoagulant activity, NOACs are not supposed to require routine monitoring due to their stable pharmacological profiles compared with warfarin.AimsTo examine situations where NOAC measurement may be useful and to provide information about methodologies available to measure NOAC-related anticoagulation activity.Summary of reviewThe routine coagulation tests, including prothrombin time, thrombin time, activated partial thromboplastin time, and international normalized ratio, have variable sensitivities to NOACs. Tests have been developed for use with specific NOACs, e.g. diluted thrombin time or chromogenic factor Xa assays. In emergency situations, such as severe bleeding, stroke, or a requirement for urgent surgery or procedures, there may be a need to assess anticoagulant activity to guide clinical decision making. In cases where neutralization of the anticoagulant effect is warranted, specific reversal agents are likely to become invaluable medical tools. Evidence to date suggests that dosing decisions for NOACs based on clinical features (e.g. age or renal function) can help optimize the benefit?risk balance without assessment of anticoagulant activity in non-emergency routine situations.ConclusionsRegular monitoring of NOAC levels does not provide benefits and cannot be recommended at present. In some specific circumstances, e.g. severe bleeding, before urgent surgery, or before thrombolysis, measurement may be beneficial to assess whether a patient is actively anticoagulated. The availability of NOAC-specific reversal agents may change management practices in emergencies. | ||
| 700 | 1 | |a Steiner, Thorsten |d 1961- |e VerfasserIn |0 (DE-588)118107623 |0 (DE-627)079247407 |0 (DE-576)291718779 |4 aut | |
| 700 | 1 | |a Purrucker, Jan |d 1982- |e VerfasserIn |0 (DE-588)142755281 |0 (DE-627)638930405 |0 (DE-576)333199219 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of stroke |d London : Sage, 2005 |g 11(2016), 7, Seite 748-758 |h Online-Ressource |w (DE-627)503720291 |w (DE-600)2211666-7 |w (DE-576)306832739 |x 1747-4949 |7 nnas |a Measuring non-vitamin K antagonist oral anticoagulant levels When is it appropriate and which methods should be used? |
| 773 | 1 | 8 | |g volume:11 |g year:2016 |g number:7 |g pages:748-758 |g extent:11 |a Measuring non-vitamin K antagonist oral anticoagulant levels When is it appropriate and which methods should be used? |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/1747493016659671 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1177/1747493016659671 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171206 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 142755281 |a Purrucker, Jan |m 142755281:Purrucker, Jan |d 910000 |d 911100 |e 910000PP142755281 |e 911100PP142755281 |k 0/910000/ |k 1/910000/911100/ |p 4 |y j | ||
| 998 | |g 118107623 |a Steiner, Thorsten |m 118107623:Steiner, Thorsten |d 910000 |d 911100 |e 910000PS118107623 |e 911100PS118107623 |k 0/910000/ |k 1/910000/911100/ |p 3 | ||
| 999 | |a KXP-PPN1566090474 |e 2989280790 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"titleAlt":[{"title":"official journal of the International Stroke Society"}],"disp":"Measuring non-vitamin K antagonist oral anticoagulant levels When is it appropriate and which methods should be used?International journal of stroke","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Volume 1, issue 1 (February 2006)-"],"note":["Gesehen am 10.02.2021"],"part":{"issue":"7","extent":"11","pages":"748-758","text":"11(2016), 7, Seite 748-758","volume":"11","year":"2016"},"language":["eng"],"origin":[{"publisherPlace":"London ; Oxford [u.a.] ; Oxford [u.a.]","publisher":"Sage ; Blackwell ; Wiley-Blackwell","dateIssuedDisp":"21 November 2005-"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1747-4949"],"eki":["503720291"],"doi":["10.1111/(ISSN)1747-4949"],"zdb":["2211666-7"]},"title":[{"title_sort":"International journal of stroke","title":"International journal of stroke","subtitle":"official journal of the World Stroke Organization"}],"recId":"503720291"}],"origin":[{"dateIssuedDisp":"13 July 2016","dateIssuedKey":"2016"}],"title":[{"title":"Measuring non-vitamin K antagonist oral anticoagulant levels","subtitle":"When is it appropriate and which methods should be used?","title_sort":"Measuring non-vitamin K antagonist oral anticoagulant levels"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"11 S."}],"id":{"doi":["10.1177/1747493016659671"],"eki":["1566090474"]},"person":[{"role":"aut","family":"Drouet","given":"Ludovic","display":"Drouet, Ludovic"},{"display":"Steiner, Thorsten","given":"Thorsten","family":"Steiner","role":"aut"},{"display":"Purrucker, Jan","given":"Jan","family":"Purrucker","role":"aut"}],"recId":"1566090474","note":["Gesehen am 06.12.2017"],"language":["eng"],"name":{"displayForm":["Ludovic Drouet, Claire Bal dit Sollier, Thorsten Steiner and Jan Purrucker"]}} | ||
| SRT | |a DROUETLUDOMEASURINGN1320 | ||