An in-vitro evaluation of three types of drug-eluting microspheres loaded with irinotecan
To compare the mechanical and chemical properties of three commercially available microspheres loaded with irinotecan. LifePearl (200 µm), DC Bead (100-300 µm), and Tandem (100 µm) microspheres were loaded with irinotecan. For loading, elution, and stability determinations, irinotecan concentrations...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 July 2016
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| In: |
Anti-cancer drugs
Year: 2016, Volume: 27, Issue: 9, Pages: 873-878 |
| ISSN: | 1473-5741 |
| DOI: | 10.1097/CAD.0000000000000408 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1097/CAD.0000000000000408 Verlag, Volltext: http://journals.lww.com/anti-cancerdrugs/pages/articleviewer.aspx?year=2016&issue=10000&article=00009&type=abstract 
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| Author Notes: | Philippe L. Pereira, Stephen Plotkin, Renee Yu, Allison Sutter, Yue Wu, Christof M. Sommer, Gregory M. Cruise |
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| 520 | |a To compare the mechanical and chemical properties of three commercially available microspheres loaded with irinotecan. LifePearl (200 µm), DC Bead (100-300 µm), and Tandem (100 µm) microspheres were loaded with irinotecan. For loading, elution, and stability determinations, irinotecan concentrations were quantified using validated high-performance liquid chromatography methods. In-vitro elution was performed over 24 h using a USP 4 dissolution apparatus. Diameter measurements were performed using light microscopy. Time in suspension was considered as the time required for the microspheres to vacate 1/3 of the volume. All three microsphere types rapidly loaded irinotecan, with more than 95% loading at 1 h. In-vitro elution of irinotecan was rapid for LifePearl and DC Bead microspheres, with more than 98% elution at 1 h, and delayed for Tandem microspheres, with about 70% elution at 6 h. After loading with irinotecan, the average diameter of LifePearl and DC Bead microspheres was reduced by 9 and 18%, respectively, and was unchanged for Tandem microspheres. All three microsphere types lost 4-6% of the loaded irinotecan almost immediately upon placement in contrast: water and contrast: 5% dextrose, but further losses were minimal over 2 weeks. LifePearl microspheres remained longer in suspension (392±23 s) compared with DC Bead (154±13 s, P<0.001) and Tandem (198±19 s, P<0.001) microspheres. All three microsphere types load irinotecan rapidly. LifePearl and DC Bead microspheres elute irinotecan rapidly. Elution is delayed with Tandem microspheres. LifePearl microspheres show the longest time in suspension. | ||
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