Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany
Objectives: Aspergillus fumigatus is the most common agent of invasive aspergillosis (IA). In recent years, resistance to triazoles, the mainstay of IA therapy, has emerged in different countries worldwide. IA caused by azole-resistant A. fumigatus (ARAF) shows an exceedingly high mortality. In this...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 January 2015
|
| In: |
The journal of antimicrobial chemotherapy
Year: 2015, Volume: 70, Issue: 5, Pages: 1522-1526 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/dku566 |
| Online Access: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.1093/jac/dku566 Verlag, teilw. kostenfrei, Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/jac/article/70/5/1522/691319 
|
| Author Notes: | J. Steinmann, A. Hamprecht, M.J.G.T. Vehreschild, O.A. Cornely, D. Buchheidt, B. Spiess, M. Koldehoff, J. Buer, J.F. Meis and P.-M. Rath |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1566340497 | ||
| 003 | DE-627 | ||
| 005 | 20220814043255.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171213s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/jac/dku566 |2 doi | |
| 035 | |a (DE-627)1566340497 | ||
| 035 | |a (DE-576)496340492 | ||
| 035 | |a (DE-599)BSZ496340492 | ||
| 035 | |a (OCoLC)1340983515 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Steinmann, Jörg Helmut |d 1978- |e VerfasserIn |0 (DE-588)134133048 |0 (DE-627)561350337 |0 (DE-576)300332483 |4 aut | |
| 245 | 1 | 0 | |a Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany |c J. Steinmann, A. Hamprecht, M.J.G.T. Vehreschild, O.A. Cornely, D. Buchheidt, B. Spiess, M. Koldehoff, J. Buer, J.F. Meis and P.-M. Rath |
| 264 | 1 | |c 27 January 2015 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.12.2017 | ||
| 520 | |a Objectives: Aspergillus fumigatus is the most common agent of invasive aspergillosis (IA). In recent years, resistance to triazoles, the mainstay of IA therapy, has emerged in different countries worldwide. IA caused by azole-resistant A. fumigatus (ARAF) shows an exceedingly high mortality. In this study, IA due to ARAF isolates in HSCT recipients in Germany was investigated. Methods: The epidemiology of azole resistance in IA was analysed in two German haematology departments. Between 2012 and 2013, 762 patients received HSCT in Essen (n=388) and Cologne (n=374). Susceptibility testing of A. fumigatus isolates was performed by Etest, followed by EUCAST broth microdilution testing if elevated MICs were recorded. In all ARAF isolates the cyp51A gene was sequenced and the genotype was determined by microsatellite typing using nine short tandem repeats. Results: In total, A. fumigatus was recovered from 27 HSCT recipients. Eight patients had azole-resistant IA after HSCT, and seven of the cases were fatal (88%). All except one patient received antifungal prophylaxis (in five cases triazoles). TR34/L98H was the most common mutation (n=5), followed by TR46/Y121F/T289A (n=2). In one resistant isolate no cyp51A mutation was detected. Genotyping revealed genetic diversity within the German ARAF isolates and no clustering with resistant isolates from the Netherlands, India and France. Conclusions: This report highlights the emergence of azole-resistant IA with TR34/L98H and TR46/Y121F/T289A mutations in HSCT patients in Germany and underscores the need for systematic antifungal susceptibility testing of A. fumigatus. | ||
| 700 | 1 | |a Buchheidt, Dieter |d 1955- |e VerfasserIn |0 (DE-588)1028287461 |0 (DE-627)730538621 |0 (DE-576)375787380 |4 aut | |
| 700 | 1 | |a Spiess, Birgit |d 1972- |e VerfasserIn |0 (DE-588)1028287496 |0 (DE-627)730538699 |0 (DE-576)37578764X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of antimicrobial chemotherapy |d Oxford : Oxford Univ. Press, 1975 |g 70(2015), 5, Seite 1522-1526 |h Online-Ressource |w (DE-627)266876838 |w (DE-600)1467478-6 |w (DE-576)075144972 |x 1460-2091 |7 nnas |a Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany |
| 773 | 1 | 8 | |g volume:70 |g year:2015 |g number:5 |g pages:1522-1526 |g extent:5 |a Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/jac/dku566 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/jac/article/70/5/1522/691319 |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171213 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1028287496 |a Spiess, Birgit |m 1028287496:Spiess, Birgit |d 60000 |d 61200 |e 60000PS1028287496 |e 61200PS1028287496 |k 0/60000/ |k 1/60000/61200/ |p 6 | ||
| 998 | |g 1028287461 |a Buchheidt, Dieter |m 1028287461:Buchheidt, Dieter |d 60000 |d 61200 |e 60000PB1028287461 |e 61200PB1028287461 |k 0/60000/ |k 1/60000/61200/ |p 5 | ||
| 999 | |a KXP-PPN1566340497 |e 2989844619 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1566340497"],"doi":["10.1093/jac/dku566"]},"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"27 January 2015"}],"name":{"displayForm":["J. Steinmann, A. Hamprecht, M.J.G.T. Vehreschild, O.A. Cornely, D. Buchheidt, B. Spiess, M. Koldehoff, J. Buer, J.F. Meis and P.-M. Rath"]},"relHost":[{"titleAlt":[{"title":"JAC"}],"part":{"pages":"1522-1526","issue":"5","year":"2015","extent":"5","volume":"70","text":"70(2015), 5, Seite 1522-1526"},"pubHistory":["1.1975 -"],"recId":"266876838","language":["eng"],"note":["Gesehen am 27.10.21"],"disp":"Emergence of azole-resistant invasive aspergillosis in HSCT recipients in GermanyThe journal of antimicrobial chemotherapy","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"journal of antimicrobial chemotherapy","title":"The journal of antimicrobial chemotherapy","subtitle":"JAC"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1467478-6"],"eki":["266876838"],"issn":["1460-2091"]},"origin":[{"dateIssuedDisp":"1975-","publisher":"Oxford Univ. Press","dateIssuedKey":"1975","publisherPlace":"Oxford"}],"name":{"displayForm":["the British Society for Antimicrobial Chemotherapy"]}}],"physDesc":[{"extent":"5 S."}],"title":[{"title":"Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany","title_sort":"Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany"}],"person":[{"given":"Jörg Helmut","family":"Steinmann","role":"aut","display":"Steinmann, Jörg Helmut","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Buchheidt, Dieter","roleDisplay":"VerfasserIn","given":"Dieter","family":"Buchheidt"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Spiess, Birgit","given":"Birgit","family":"Spiess"}],"language":["eng"],"recId":"1566340497","note":["Gesehen am 13.12.2017"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a STEINMANNJEMERGENCEO2720 | ||