Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats: a comparative study
Propofol (2,6-diisopropylphenol) is a safe and widely used anaesthetic, but due to low water solubility and high lipophilicity a difficult compound to formulate. The solubility of propofol in the semifluorinated alkane perfluorohexyloctane (F6H8) is very high (>300mg/ml). In the present work we i...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 May 2015
|
| In: |
International journal of pharmaceutics
Year: 2015, Jahrgang: 486, Heft: 1/2, Pages: 69-76 |
| ISSN: | 1873-3476 |
| DOI: | 10.1016/j.ijpharm.2015.03.037 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijpharm.2015.03.037 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0378517315002537 
|
| Verfasserangaben: | Charalambos Tsagogiorgas, Sonja Theisinger, Elisabeth Heesch, Jörg Krebs, René Holm, Grietje Beck, Benito Yard |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1566351138 | ||
| 003 | DE-627 | ||
| 005 | 20240606153738.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171213s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijpharm.2015.03.037 |2 doi | |
| 035 | |a (DE-627)1566351138 | ||
| 035 | |a (DE-576)496351133 | ||
| 035 | |a (DE-599)BSZ496351133 | ||
| 035 | |a (OCoLC)1340983536 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tsagogiorgas, Charalambos |d 1974- |e VerfasserIn |0 (DE-588)129802255 |0 (DE-627)480699747 |0 (DE-576)297843044 |4 aut | |
| 245 | 1 | 0 | |a Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats |b a comparative study |c Charalambos Tsagogiorgas, Sonja Theisinger, Elisabeth Heesch, Jörg Krebs, René Holm, Grietje Beck, Benito Yard |
| 264 | 1 | |c 30 May 2015 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.12.2017 | ||
| 520 | |a Propofol (2,6-diisopropylphenol) is a safe and widely used anaesthetic, but due to low water solubility and high lipophilicity a difficult compound to formulate. The solubility of propofol in the semifluorinated alkane perfluorohexyloctane (F6H8) is very high (>300mg/ml). In the present work we investigate if a F6H8-based emulsion could be used as a new intravenous drug delivery system for propofol from a pharmacokinetic, pharmacodynamic and safety point of view. The pharmacokinetic parameters were evaluated after an intravenous bolus injection of either Disoprivan® or a F6H8-based propofol emulsion in Wistar rats. The onset and end of sedation after multiple dosings (5, 10 and 15mg/kg bw) were examined. Clinical chemistry and histology were assessed. No significant difference was found for any of the pharmacokinetic parameters. No differences in the onset nor the end of sedation in the tested dosages could be detected. Histology scores revealed no differences. A slightly increased alanine aminotransferase (ALT) was measured after multiple application of the F6H8-propofol emulsion. In conclusion, the F6H8-propofol emulsion showed no significant different pharmacokinetics and sedation properties, compared to a commercial soy-based propofol emulsion. Further, no toxic effects could be detected on the F6H8 emulsion indicating it was a safe excipient in rats. | ||
| 650 | 4 | |a Drug delivery | |
| 650 | 4 | |a Emulsion | |
| 650 | 4 | |a F6H8 | |
| 650 | 4 | |a Perfluorocarbon | |
| 650 | 4 | |a Propofol | |
| 650 | 4 | |a Semifluorinated alkane | |
| 700 | 1 | |a Heesch, Elisabeth Sabine |d 1986- |e VerfasserIn |0 (DE-588)1117946797 |0 (DE-627)871741032 |0 (DE-576)47940755X |4 aut | |
| 700 | 1 | |a Krebs, Jörg |d 1978- |e VerfasserIn |0 (DE-588)131961713 |0 (DE-627)516320017 |0 (DE-576)298863081 |4 aut | |
| 700 | 1 | |a Beck, Grietje |d 1965- |e VerfasserIn |0 (DE-588)114399360 |0 (DE-627)647300117 |0 (DE-576)337555028 |4 aut | |
| 700 | 1 | |a Yard, Benito A. |d 1961- |e VerfasserIn |0 (DE-588)1025110633 |0 (DE-627)721145892 |0 (DE-576)369951735 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of pharmaceutics |d New York, NY [u.a.] : Elsevier, 1978 |g 486(2015), 1/2, Seite 69-76 |h Online-Ressource |w (DE-627)301512817 |w (DE-600)1484643-3 |w (DE-576)081952708 |x 1873-3476 |7 nnas |a Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats a comparative study |
| 773 | 1 | 8 | |g volume:486 |g year:2015 |g number:1/2 |g pages:69-76 |g extent:8 |a Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats a comparative study |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijpharm.2015.03.037 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0378517315002537 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171213 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1025110633 |a Yard, Benito A. |m 1025110633:Yard, Benito A. |d 60000 |d 61400 |e 60000PY1025110633 |e 61400PY1025110633 |k 0/60000/ |k 1/60000/61400/ |p 7 |y j | ||
| 998 | |g 114399360 |a Beck, Grietje |m 114399360:Beck, Grietje |d 60000 |d 61600 |e 60000PB114399360 |e 61600PB114399360 |k 0/60000/ |k 1/60000/61600/ |p 6 | ||
| 998 | |g 131961713 |a Krebs, Jörg |m 131961713:Krebs, Jörg |d 60000 |d 61600 |e 60000PK131961713 |e 61600PK131961713 |k 0/60000/ |k 1/60000/61600/ |p 4 | ||
| 998 | |g 1117946797 |a Heesch, Elisabeth Sabine |m 1117946797:Heesch, Elisabeth Sabine |d 60000 |d 63000 |e 60000PH1117946797 |e 63000PH1117946797 |k 0/60000/ |k 1/60000/63000/ |p 3 | ||
| 998 | |g 129802255 |a Tsagogiorgas, Charalambos |m 129802255:Tsagogiorgas, Charalambos |d 60000 |d 61600 |e 60000PT129802255 |e 61600PT129802255 |k 0/60000/ |k 1/60000/61600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1566351138 |e 2989858407 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 13.12.2017"],"name":{"displayForm":["Charalambos Tsagogiorgas, Sonja Theisinger, Elisabeth Heesch, Jörg Krebs, René Holm, Grietje Beck, Benito Yard"]},"physDesc":[{"extent":"8 S."}],"title":[{"title_sort":"Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats","subtitle":"a comparative study","title":"Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats"}],"language":["eng"],"origin":[{"dateIssuedDisp":"30 May 2015","dateIssuedKey":"2015"}],"recId":"1566351138","id":{"doi":["10.1016/j.ijpharm.2015.03.037"],"eki":["1566351138"]},"relHost":[{"pubHistory":["1.1978 -"],"part":{"volume":"486","pages":"69-76","text":"486(2015), 1/2, Seite 69-76","extent":"8","year":"2015","issue":"1/2"},"disp":"Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats a comparative studyInternational journal of pharmaceutics","recId":"301512817","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 23.09.2021"],"title":[{"title":"International journal of pharmaceutics","title_sort":"International journal of pharmaceutics"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1978","dateIssuedDisp":"1978-","publisherPlace":"New York, NY [u.a.]","publisher":"Elsevier"}],"id":{"issn":["1873-3476"],"zdb":["1484643-3"],"eki":["301512817"]}}],"person":[{"display":"Tsagogiorgas, Charalambos","family":"Tsagogiorgas","role":"aut","given":"Charalambos"},{"given":"Elisabeth Sabine","family":"Heesch","display":"Heesch, Elisabeth Sabine","role":"aut"},{"role":"aut","display":"Krebs, Jörg","family":"Krebs","given":"Jörg"},{"given":"Grietje","role":"aut","family":"Beck","display":"Beck, Grietje"},{"given":"Benito A.","family":"Yard","display":"Yard, Benito A.","role":"aut"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a TSAGOGIORGEVALUATION3020 | ||