rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Bistability of cell-matrix adhesions resulting from nonlinear receptor-ligand dynamics
  name:
    name part: Erdmann, Thorsten
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Schwarz, Ulrich S.
    name part: 1966-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 3
  abstract: Bistability is a major mechanism for cellular decision making and usually results from positive feedback in biochemical control systems. Here we show theoretically that bistability between unbound and bound states of adhesion clusters results from positive feedback mediated by structural rather than biochemical processes, namely by receptor-ligand dissociation and association dynamics that depend nonlinearly on mechanical force and receptor-ligand separation. For small cell-matrix adhesions, we find rapid switching between unbound and bound states, which in the initial stages of adhesion allows the cell to explore its environment through many transient adhesions.
  note: Thorsten Erdmann and Ulrich S. Schwarz
  note: Gesehen am 10.07.2020
  note: 2006
  classification: 29
  related item:
    origin info:
      publisher: 2006
  related item:
    title info:
      title: Biophysical journal
    name:
      name part: Bistability of cell-matrix adhesions resulting from nonlinear receptor-ligand dynamics
    origin info:
      publisher: Cambridge, Mass. : Cell Press, 1960
    physical description:
      extent: Online-Ressource
    identifier: 1542-0086
    identifier: (DE-627)270425357
    identifier: (DE-600)1477214-0
    identifier: (DE-576)091017602
    part:
      text: 91(2006), 6, Seite L60-L62
  related item:
    name:
      name part: Bistability of cell-matrix adhesions resulting from nonlinear receptor-ligand dynamics
    part:
      text: volume:91
    part:
      text: year:2006
    part:
      text: number:6
    part:
      text: pages:L60-L62
    part:
      text: extent:3
  identifier: http://dx.doi.org/10.1529/biophysj.106.090209
  identifier: http://www.sciencedirect.com/science/article/pii/S0006349506719129
  record info:
    record content source: DE-627
    record creation date: 171215
    record change date: 20220814044008.0
    record identifier: 1566413419
    language of cataloging:
      language term: ger