L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events
L-selectin-mediated tethers result in leukocyte rolling only above a threshold in shear. Here we present biophysical modeling based on recently published data from flow chamber experiments, which supports the interpretation that L-selectin-mediated tethers below the shear threshold correspond to sin...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2004
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| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2004, Jahrgang: 101, Heft: 18, Pages: 6940-6945 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0305822101 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1073/pnas.0305822101 Verlag, Volltext: http://www.pnas.org/content/101/18/6940 
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| Verfasserangaben: | Ulrich S. Schwarz and Ronen Alon |
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L-selectin mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events
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