rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Measurement of cellular forces at focal adhesions using elastic micro-patterned substrates
  name:
    name part: Schwarz, Ulrich S.
    name part: 1966-
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 8
  abstract: Mechanical force is known to play an important role in the regulation of cellular behaviour, including adhesion, motility, differentiation and proliferation. For stationary, mechanically active cells like fibroblasts, adhesion to flat substrates occurs mainly at sites of focal adhesions, which are micron-sized protein aggregates at the plasma membrane, which on the cytoplasmic side connect to the actin cytoskeleton. In recent years, evidence has been growing that focal adhesions act as mechanosensors which convert mechanical force into biochemical signalling. We have investigated the relationship between force and aggregation at focal adhesions by a new method which combines elastic micro-patterned substrates (to record substrate deformation), fluorescence labelling of focal adhesion proteins (to monitor aggregation) and numerical solution of the inverse problem of linear elasticity theory (to calculate forces at focal adhesions). We have found that force correlates linearly with lateral size of aggregation, with a stress constant of 5.5 nN/μm2. This finding indicates that mechanosensing involves regulation of aggregation.
  note: U.S. Schwarz, N.Q. Balaban, D. Riveline, L. Addadi, A. Bershadsky, S.A. Safran, B. Geiger
  note: Published online: 19 December 2002
  note: Gesehen am 15.12.2017
  note: 2002
  subject:
    topic: Cell-matrix adhesion
  subject:
    topic: Focal adhesions
  subject:
    topic: Elasticity theory
  subject:
    topic: Integrins
  subject:
    topic: Inverse problems
  subject:
    topic: Mechanosensor
  classification: 29
  related item:
    origin info:
      publisher: 2002
  related item:
    title info:
      title: Materials science & engineering. C, Materials for biological applications
    name:
      name part: Measurement of cellular forces at focal adhesions using elastic micro-patterned substrates
    origin info:
      publisher: Amsterdam : Elsevier, 1993
    physical description:
      extent: Online-Ressource
    identifier: 1873-0191
    identifier: (DE-627)320500551
    identifier: (DE-600)2012160-X
    identifier: (DE-576)259484695
    part:
      text: 23(2003), 3, Seite 387-394
  related item:
    name:
      name part: Measurement of cellular forces at focal adhesions using elastic micro-patterned substrates
    part:
      text: volume:23
    part:
      text: year:2003
    part:
      text: number:3
    part:
      text: pages:387-394
    part:
      text: extent:8
  identifier: http://dx.doi.org/10.1016/S0928-4931(02)00309-0
  identifier: http://www.sciencedirect.com/science/article/pii/S0928493102003090
  record info:
    record content source: DE-627
    record creation date: 171215
    record change date: 20220814044400.0
    record identifier: 1566421624
    language of cataloging:
      language term: ger