Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases
DNA (6-4)-photolyases are enzymes initiating cleavage of mutagenic pyrimidine (6-4) pyrimidone photolesions by a photoinitiated electron transfer from flavin adenine dinucleotide to the lesion. Using state-of-the-art quantum chemical calculations, we present the first energetically feasible molecula...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 3, 2012
|
| In: |
The journal of physical chemistry letters
Year: 2012, Jahrgang: 3, Heft: 2, Pages: 227-230 |
| ISSN: | 1948-7185 |
| DOI: | 10.1021/jz201587v |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1021/jz201587v
|
| Verfasserangaben: | Shirin Faraji and Andreas Dreuw |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1566484499 | ||
| 003 | DE-627 | ||
| 005 | 20230426064433.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171218s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/jz201587v |2 doi | |
| 035 | |a (DE-627)1566484499 | ||
| 035 | |a (DE-576)496484494 | ||
| 035 | |a (DE-599)BSZ496484494 | ||
| 035 | |a (OCoLC)1340983595 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Faraji, Shirin |d 1981- |e VerfasserIn |0 (DE-588)14362654X |0 (DE-627)704550512 |0 (DE-576)338050272 |4 aut | |
| 245 | 1 | 0 | |a Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases |c Shirin Faraji and Andreas Dreuw |
| 264 | 1 | |c January 3, 2012 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.12.2017 | ||
| 520 | |a DNA (6-4)-photolyases are enzymes initiating cleavage of mutagenic pyrimidine (6-4) pyrimidone photolesions by a photoinitiated electron transfer from flavin adenine dinucleotide to the lesion. Using state-of-the-art quantum chemical calculations, we present the first energetically feasible molecular repair mechanism. The initial step is electron transfer coupled to proton transfer from the protonated His345 to the N3′ nitrogen of the pyrimidone thymine of the lesion, which proceeds simultaneously with intramolecular OH transfer in a concerted reaction without formation of an oxetane or isolated water molecule intermediate. In contrast to previously suggested mechanisms, this newly identified pathway requires neither a two-photon process nor electronic excitation of the photolesion. Indeed, the recognition that the initial electron transfer is coupled to the proton transfer was critically important for clarification of the mechanism. | ||
| 700 | 1 | |a Dreuw, Andreas |d 1972- |e VerfasserIn |0 (DE-588)1060214598 |0 (DE-627)799305626 |0 (DE-576)416304974 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of physical chemistry letters |d Washington, DC : ACS, 2010 |g 3(2012), 2, Seite 227-230 |h Online-Ressource |w (DE-627)612168581 |w (DE-600)2522838-9 |w (DE-576)315319089 |x 1948-7185 |7 nnas |a Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases |
| 773 | 1 | 8 | |g volume:3 |g year:2012 |g number:2 |g pages:227-230 |g extent:4 |a Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/jz201587v |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171218 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1060214598 |a Dreuw, Andreas |m 1060214598:Dreuw, Andreas |d 700000 |d 708000 |e 700000PD1060214598 |e 708000PD1060214598 |k 0/700000/ |k 1/700000/708000/ |p 2 |y j | ||
| 998 | |g 14362654X |a Faraji, Shirin |m 14362654X:Faraji, Shirin |d 700000 |d 708000 |d 120000 |d 120300 |e 700000PF14362654X |e 708000PF14362654X |e 120000PF14362654X |e 120300PF14362654X |k 0/700000/ |k 1/700000/708000/ |k 0/120000/ |k 1/120000/120300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1566484499 |e 299014014X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"January 3, 2012","dateIssuedKey":"2012"}],"relHost":[{"recId":"612168581","name":{"displayForm":["American Chemical Society"]},"origin":[{"publisherPlace":"Washington, DC","dateIssuedKey":"2010","dateIssuedDisp":"2010-","publisher":"ACS"}],"id":{"eki":["612168581"],"issn":["1948-7185"],"zdb":["2522838-9"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"journal of physical chemistry letters","title":"The journal of physical chemistry letters"}],"pubHistory":["1.2010 -"],"note":["Gesehen am 02.01.2013"],"part":{"pages":"227-230","extent":"4","issue":"2","text":"3(2012), 2, Seite 227-230","year":"2012","volume":"3"},"language":["eng"],"titleAlt":[{"title":"JPCLett"}],"disp":"Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyasesThe journal of physical chemistry letters","type":{"bibl":"periodical","media":"Online-Ressource"}}],"id":{"eki":["1566484499"],"doi":["10.1021/jz201587v"]},"physDesc":[{"extent":"4 S."}],"title":[{"title_sort":"Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases","title":"Proton-transfer-steered mechanism of photolesion repair by (6-4)-photolyases"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 18.12.2017"],"recId":"1566484499","person":[{"family":"Faraji","role":"aut","given":"Shirin","display":"Faraji, Shirin"},{"display":"Dreuw, Andreas","given":"Andreas","role":"aut","family":"Dreuw"}],"name":{"displayForm":["Shirin Faraji and Andreas Dreuw"]},"language":["eng"]} | ||
| SRT | |a FARAJISHIRPROTONTRAN3201 | ||