Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently needed. To this end, we compiled a compr...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 November 2015
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| In: |
BMC systems biology
Year: 2015, Volume: 9 |
| ISSN: | 1752-0509 |
| DOI: | 10.1186/s12918-015-0229-0 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12918-015-0229-0 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12918-015-0229-0 
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| Author Notes: | Kerstin Abshagen, Matthias König, Andreas Hoppe, Isabell Müller, Matthias Ebert, Honglei Weng, Herrmann-Georg Holzhütter, Ulrich M. Zanger, Johannes Bode, Brigitte Vollmar, Maria Thomas and Steven Dooley |
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| 245 | 1 | 0 | |a Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice |c Kerstin Abshagen, Matthias König, Andreas Hoppe, Isabell Müller, Matthias Ebert, Honglei Weng, Herrmann-Georg Holzhütter, Ulrich M. Zanger, Johannes Bode, Brigitte Vollmar, Maria Thomas and Steven Dooley |
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| 520 | |a Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently needed. To this end, we compiled a comprehensive data set of serum markers, histological parameters and transcript profiles at 8 time points of disease progression after bile duct ligation (BDL) in mice, aiming at identifying a set of parameters that could be used as robust biomarkers for transition of different disease progression phases. | ||
| 650 | 4 | |a Bile duct ligation | |
| 650 | 4 | |a Cell proliferation | |
| 650 | 4 | |a Cholestasis | |
| 650 | 4 | |a Fibrosis | |
| 650 | 4 | |a Liver injury | |
| 650 | 4 | |a Morphological profiling | |
| 650 | 4 | |a Mouse | |
| 650 | 4 | |a Systems biology | |
| 650 | 4 | |a Virtual liver network | |
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