Renal transplantation in HIV-positive renal transplant recipients: experience at the Mannheim University Hospital
Renal transplantation in HIV-positive patients with end-stage renal disease has in recent years become a successful treatment option. We report two patients who underwent renal transplantation using a combination of basiliximab, calcineurin inhibitors, mycophenolate mofetil (MMF), and steroids with...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2015
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| In: |
Transplantation proceedings
Year: 2015, Volume: 47, Issue: 9, Pages: 2791-2794 |
| ISSN: | 1873-2623 |
| DOI: | 10.1016/j.transproceed.2015.09.064 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.transproceed.2015.09.064 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0041134515009938 |
| Author Notes: | J. Haas, T. Singer, K. Nowak, J. Brust, U. Göttmann, P. Schnülle, B. Krüger, B.K. Krämer, U. Benck |
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| 520 | |a Renal transplantation in HIV-positive patients with end-stage renal disease has in recent years become a successful treatment option. We report two patients who underwent renal transplantation using a combination of basiliximab, calcineurin inhibitors, mycophenolate mofetil (MMF), and steroids with a “non-interacting” antiretroviral combination therapy consisting of stavudine or abacavir, lamivudine, and nevirapine. We observed no acute rejection but a BK polyomavirus infection in both patients. In conclusion, a quadruple immunosuppression with an interleukin 2 receptor antagonist, a calcineurin inhibitor, MMF, and steroids appears to be advisable to prevent high rates of acute rejection, but if possible thereafter immunosuppression should be tapered rapidly (eg, MMF stop, prednisolone dose 5 mg/d). The selection of antiretroviral agents should avoid compounds that interact severely with the immunosuppression used. | ||
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