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A transient ischemic environment induces reversible compaction of chromatin

Cells detect and adapt to hypoxic and nutritional stress through immediate transcriptional, translational and metabolic responses. The environmental effects of ischemia on chromatin nanostructure were investigated using single molecule localization microscopy of DNA binding dyes and of acetylated hi...

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Bibliographic Details
Main Authors: Kirmes, Ina Caroline (Author) , Prakash, Kirti (Author) , Ma, Dongyu (Author) , Cremer, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 5 November 2015
In: Genome biology
Year: 2015, Volume: 16, Pages: 246
ISSN:1474-760X
DOI:10.1186/s13059-015-0802-2
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13059-015-0802-2
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13059-015-0802-2
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Author Notes:Ina Kirmes, Aleksander Szczurek, Kirti Prakash, Iryna Charapitsa, Christina Heiser, Michael Musheev, Florian Schock, Karolina Fornalczyk, Dongyu Ma, Udo Birk, Christoph Cremer and George Reid
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Summary:Cells detect and adapt to hypoxic and nutritional stress through immediate transcriptional, translational and metabolic responses. The environmental effects of ischemia on chromatin nanostructure were investigated using single molecule localization microscopy of DNA binding dyes and of acetylated histones, by the sensitivity of chromatin to digestion with DNAseI, and by fluorescence recovery after photobleaching (FRAP) of core and linker histones.
Item Description:Gesehen am 21.12.2017
Physical Description:Online Resource
ISSN:1474-760X
DOI:10.1186/s13059-015-0802-2

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