Buchumschlag

GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis

Summary The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC pati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ye, Qinghai (VerfasserIn) , Rössler, Stephanie (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 August 2016
In: Cancer cell
Year: 2016, Jahrgang: 30, Heft: 3, Pages: 444-458
ISSN:1878-3686
DOI:10.1016/j.ccell.2016.07.017
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.ccell.2016.07.017
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1535610816303518
Volltext
Verfasserangaben:Qing-Hai Ye, Wen-Wei Zhu, Ju-Bo Zhang, Yi Qin, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues, Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie, Qiong-Zhu Dong, Zhao-You Tang, Xin Wei Wang, Lun-Xiu Qin

MARC

LEADER 00000caa a2200000 c 4500
001 156674654X
003 DE-627
005 20250206094539.0
007 cr uuu---uuuuu
008 171222s2016 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ccell.2016.07.017  |2 doi 
035 |a (DE-627)156674654X 
035 |a (DE-576)496746545 
035 |a (DE-599)BSZ496746545 
035 |a (OCoLC)1340983553 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Ye, Qinghai  |e VerfasserIn  |0 (DE-588)1149418818  |0 (DE-627)1009657038  |0 (DE-576)496746642  |4 aut 
245 1 0 |a GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis  |c Qing-Hai Ye, Wen-Wei Zhu, Ju-Bo Zhang, Yi Qin, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues, Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie, Qiong-Zhu Dong, Zhao-You Tang, Xin Wei Wang, Lun-Xiu Qin 
264 1 |c 25 August 2016 
300 |a 15 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.12.2017 
520 |a Summary The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC. 
700 1 |a Rössler, Stephanie  |e VerfasserIn  |0 (DE-588)1071122991  |0 (DE-627)825603277  |0 (DE-576)255690843  |4 aut 
773 0 8 |i Enthalten in  |t Cancer cell  |d Cambridge, Mass. : Cell Press, 2002  |g 30(2016), 3, Seite 444-458  |h Online-Ressource  |w (DE-627)343970082  |w (DE-600)2074034-7  |w (DE-576)097935972  |x 1878-3686  |7 nnas  |a GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis 
773 1 8 |g volume:30  |g year:2016  |g number:3  |g pages:444-458  |g extent:15  |a GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis 
856 4 0 |u http://dx.doi.org/10.1016/j.ccell.2016.07.017  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S1535610816303518  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20171222 
993 |a Article 
994 |a 2016 
998 |g 1071122991  |a Rössler, Stephanie  |m 1071122991:Rössler, Stephanie  |d 910000  |d 912000  |e 910000PR1071122991  |e 912000PR1071122991  |k 0/910000/  |k 1/910000/912000/  |p 10 
999 |a KXP-PPN156674654X  |e 2991467134 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 22.12.2017"],"name":{"displayForm":["Qing-Hai Ye, Wen-Wei Zhu, Ju-Bo Zhang, Yi Qin, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues, Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie, Qiong-Zhu Dong, Zhao-You Tang, Xin Wei Wang, Lun-Xiu Qin"]},"title":[{"title":"GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis","title_sort":"GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis"}],"language":["eng"],"physDesc":[{"extent":"15 S."}],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"25 August 2016"}],"recId":"156674654X","id":{"doi":["10.1016/j.ccell.2016.07.017"],"eki":["156674654X"]},"relHost":[{"id":{"issn":["1878-3686"],"zdb":["2074034-7"],"eki":["343970082"]},"origin":[{"publisher":"Cell Press ; Elsevier","publisherPlace":"Cambridge, Mass. ; New York, NY","dateIssuedKey":"2002","dateIssuedDisp":"2002-"}],"note":["Gesehen am 28.02.11"],"title":[{"title":"Cancer cell","title_sort":"Cancer cell"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"343970082","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2002 -"],"disp":"GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasisCancer cell","part":{"pages":"444-458","volume":"30","text":"30(2016), 3, Seite 444-458","issue":"3","extent":"15","year":"2016"}}],"person":[{"given":"Qinghai","role":"aut","family":"Ye","display":"Ye, Qinghai"},{"given":"Stephanie","family":"Rössler","display":"Rössler, Stephanie","role":"aut"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} 
SRT |a YEQINGHAIRGOLM1MODUL2520 

Ähnliche Einträge