DCE-MRI of the breast in a stand-alone setting outside a complementary strategy: results of the TK-study
Objectives: To evaluate the accuracy of MRI of the breast (DCE-MRI) in a stand-alone setting with extended indications. Materials and methods: According to the inclusion criteria, breast specialists were invited to refer patients to our institution for DCE-MRI. Depending on the MR findings, patients...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2015
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| In: |
European radiology
Year: 2015, Jahrgang: 25, Heft: 6, Pages: 1793-1800 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-014-3580-4 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00330-014-3580-4 Verlag, Volltext: https://link.springer.com/article/10.1007/s00330-014-3580-4 
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| Verfasserangaben: | Clemens G. Kaiser, C. Reich, M. Dietzel, P.A.T. Baltzer, J. Krammer, K. Wasser, S.O. Schoenberg, W.A. Kaiser |
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| 245 | 1 | 0 | |a DCE-MRI of the breast in a stand-alone setting outside a complementary strategy |b results of the TK-study |c Clemens G. Kaiser, C. Reich, M. Dietzel, P.A.T. Baltzer, J. Krammer, K. Wasser, S.O. Schoenberg, W.A. Kaiser |
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| 520 | |a Objectives: To evaluate the accuracy of MRI of the breast (DCE-MRI) in a stand-alone setting with extended indications. Materials and methods: According to the inclusion criteria, breast specialists were invited to refer patients to our institution for DCE-MRI. Depending on the MR findings, patients received either a follow-up or biopsy. Between 04/2006 and 12/2011 a consecutive total of 1,488 women were prospectively examined. Results: Of 1,488 included patients, 393 patients were lost to follow-up, 1,095 patients were evaluated. 124 patients were diagnosed with malignancy by DCE-MRI (76 TP, 48 FP, 971 TN, 0 FN cases). Positive cases were confirmed by histology, negative cases by MR follow-ups or patient questionnaires over the next 5 years in 1,737 cases (sensitivity 100 %; specificity 95.2 %; PPV 61.3 %; NPV 100 %; accuracy 95.5 %). For invasive cancers only (DCIS excluded), the results were 63 TP; 27 FP; 971 TP and 0 FN (sensitivity 100 %; specificity 97.2 %; PPV 70 %; NPV 100 %; accuracy 97.5 %). Conclusion: The DCE-MRI indications tested imply that negative results in DCE-MRI reliably exclude cancer. The results were achieved in a stand-alone setting (single modality diagnosis). However, these results are strongly dependent on reader experience and adequate technical standards as prerequisites for optimal diagnoses. Key Points: DCE-MRI of the breast has a high accuracy in finding breast cancer. The set of indications for DCE-MRI of the breast is still very limited. DCE-MRI can achieve a high accuracy in a ‘screening-like’ setting. Accuracy of breast DCE-MRI is strongly dependent on technique and reader experience. A negative DCE-MRI effectively excludes cancer. | ||
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