Outcome of papillary versus clear cell renal cell carcinoma varies significantly in non-metastatic disease
Renal cell carcinoma (RCC) comprises a heterogenous group of tumors. Traditionally, papillary RCC (pRCC) is associated with a favorable outcome compared to clear cell RCC (ccRCC), while other series report equivalent or worse prognosis. In this paper we comparatively evaluate outcome of pRCC versus...
Gespeichert in:
| 1. Verfasser: | |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 21, 2017
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| In: |
PLOS ONE
Year: 2017, Jahrgang: 12, Heft: 9 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0184173 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0184173 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184173 
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| Verfasserangaben: | Nina Wagener, Dominic Edelmann, Axel Benner, Richard Zigeuner, Hendrik Borgmann, Ingmar Wolff, Laura M. Krabbe, Mireia Musquera, Paolo Dell’Oglio, Umberto Capitanio, Tobias Klatte, Luca Cindolo, Matthias May, Sabine D. Brookman-May, on behalf of the European Association of Urology (EAU) Young Academic Urologists (YAU) Kidney Cancer Group |
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| 245 | 1 | 0 | |a Outcome of papillary versus clear cell renal cell carcinoma varies significantly in non-metastatic disease |c Nina Wagener, Dominic Edelmann, Axel Benner, Richard Zigeuner, Hendrik Borgmann, Ingmar Wolff, Laura M. Krabbe, Mireia Musquera, Paolo Dell’Oglio, Umberto Capitanio, Tobias Klatte, Luca Cindolo, Matthias May, Sabine D. Brookman-May, on behalf of the European Association of Urology (EAU) Young Academic Urologists (YAU) Kidney Cancer Group |
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| 520 | |a Renal cell carcinoma (RCC) comprises a heterogenous group of tumors. Traditionally, papillary RCC (pRCC) is associated with a favorable outcome compared to clear cell RCC (ccRCC), while other series report equivalent or worse prognosis. In this paper we comparatively evaluate outcome of pRCC versus ccRCC in two large multi-institutional databases (cohort study), including distribution of pRCC subtypes 1 and 2. Retrospective data of 1,943 surgically treated pRCC patients from 17 European/ North American centers between 1984-2015 were compared to 5,600 ccRCC patients from a database comprising 11 European/ North American centers (1984-2011). Median follow-up was 64.6 months. Differences between pRCC, subtypes, and ccRCC were compared with t-tests, Chi^2-tests, and exact Fisher tests. Cancer-specific mortality was analyzed with cumulative incidence curves and Cox cause-specific hazard models. The robustness of our results was examined with sensitivity analyses. We present that cancer-specific mortality rates and variables as stage, lymph node, and distant metastasis differ significantly between groups. Furthermore, we demonstrate that patients with non-metastatic pRCC had a significantly better cancer-specific mortality (HR 0.76, p = 0.007), when compared to ccRCC. Additionally, pRCC type 2 versus ccRCC exhibited no difference in cancer-specific mortality (HR 0.9, p = 0.722), whereas pRCC type 1 versus ccRCC displayed a risk of death reduced by 69% (p = 0.044). Taken together, outcome of pRCC versus ccRCC varies significantly in non-metastatic disease. Furthermore, pRCC type 2 exhibited no difference in cancer-specific mortality, whereas pRCC type 1 displayed a significantly reduced risk of death. Consequently, there is urgent need to respect histopathological entities and their subtypes, when assigning follow-up or targeted therapy to RCC patients. | ||
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| 650 | 4 | |a Lymph nodes | |
| 650 | 4 | |a Metastasis | |
| 650 | 4 | |a Multivariate analysis | |
| 650 | 4 | |a Renal cell carcinoma | |
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