CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation): guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)
Infections of the central nervous system (CNS) are infrequently diagnosed in immunocompetent patients, but they do occur in a significant proportion of patients with hematological disorders. In particular, patients undergoing allogeneic hematopoietic stem-cell transplantation carry a high risk for C...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 April 2016
|
| In: |
Annals of oncology
Year: 2016, Volume: 27, Issue: 7, Pages: 1207-1225 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdw155 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1093/annonc/mdw155 Verlag, kostenfrei, Volltext: https://academic.oup.com/annonc/article/27/7/1207/1741476 
|
| Author Notes: | M. Schmidt-Hieber, G. Silling, E. Schalk, W. Heinz, J. Panse, O. Penack, M. Christopeit, D. Buchheidt, U. Meyding-Lamadé, S. Hähnel, H. H. Wolf, M. Ruhnke, S. Schwartz and G. Maschmeyer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1567278299 | ||
| 003 | DE-627 | ||
| 005 | 20230426064453.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180117s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/annonc/mdw155 |2 doi | |
| 035 | |a (DE-627)1567278299 | ||
| 035 | |a (DE-576)497278294 | ||
| 035 | |a (DE-599)BSZ497278294 | ||
| 035 | |a (OCoLC)1340985827 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmidt-Hieber, Martin |d 1972- |e VerfasserIn |0 (DE-588)12174387X |0 (DE-627)705637158 |0 (DE-576)292862148 |4 aut | |
| 245 | 1 | 0 | |a CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation) |b guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) |c M. Schmidt-Hieber, G. Silling, E. Schalk, W. Heinz, J. Panse, O. Penack, M. Christopeit, D. Buchheidt, U. Meyding-Lamadé, S. Hähnel, H. H. Wolf, M. Ruhnke, S. Schwartz and G. Maschmeyer |
| 264 | 1 | |c 6 April 2016 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.01.2018 | ||
| 520 | |a Infections of the central nervous system (CNS) are infrequently diagnosed in immunocompetent patients, but they do occur in a significant proportion of patients with hematological disorders. In particular, patients undergoing allogeneic hematopoietic stem-cell transplantation carry a high risk for CNS infections of up to 15%. Fungi and Toxoplasma gondii are the predominant causative agents. The diagnosis of CNS infections is based on neuroimaging, cerebrospinal fluid examination and biopsy of suspicious lesions in selected patients. However, identification of CNS infections in immunocompromised patients could represent a major challenge since metabolic disturbances, side-effects of antineoplastic or immunosuppressive drugs and CNS involvement of the underlying hematological disorder may mimic symptoms of a CNS infection. The prognosis of CNS infections is generally poor in these patients, albeit the introduction of novel substances (e.g. voriconazole) has improved the outcome in distinct patient subgroups. This guideline has been developed by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) with the contribution of a panel of 14 experts certified in internal medicine, hematology/oncology, infectious diseases, intensive care, neurology and neuroradiology. Grades of recommendation and levels of evidence were categorized by using novel criteria, as recently published by the European Society of Clinical Microbiology and Infectious Diseases. | ||
| 700 | 1 | |a Buchheidt, Dieter |d 1955- |e VerfasserIn |0 (DE-588)1028287461 |0 (DE-627)730538621 |0 (DE-576)375787380 |4 aut | |
| 700 | 1 | |a Hähnel, Stefan |d 1966- |e VerfasserIn |0 (DE-588)113981937 |0 (DE-627)558821138 |0 (DE-576)289781639 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of oncology |d Amsterdam [u.a.] : Elsevier, 1990 |g 27(2016), 7, Seite 1207-1225 |h Online-Ressource |w (DE-627)320428796 |w (DE-600)2003498-2 |w (DE-576)098134345 |x 1569-8041 |7 nnas |a CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation) guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) |
| 773 | 1 | 8 | |g volume:27 |g year:2016 |g number:7 |g pages:1207-1225 |g extent:19 |a CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation) guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/annonc/mdw155 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/annonc/article/27/7/1207/1741476 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180117 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 113981937 |a Hähnel, Stefan |m 113981937:Hähnel, Stefan |d 910000 |d 911100 |e 910000PH113981937 |e 911100PH113981937 |k 0/910000/ |k 1/910000/911100/ |p 10 | ||
| 998 | |g 1028287461 |a Buchheidt, Dieter |m 1028287461:Buchheidt, Dieter |d 60000 |d 61200 |e 60000PB1028287461 |e 61200PB1028287461 |k 0/60000/ |k 1/60000/61200/ |p 8 | ||
| 999 | |a KXP-PPN1567278299 |e 2993022997 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["M. Schmidt-Hieber, G. Silling, E. Schalk, W. Heinz, J. Panse, O. Penack, M. Christopeit, D. Buchheidt, U. Meyding-Lamadé, S. Hähnel, H. H. Wolf, M. Ruhnke, S. Schwartz and G. Maschmeyer"]},"title":[{"title":"CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)","subtitle":"guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","title_sort":"CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)"}],"origin":[{"dateIssuedDisp":"6 April 2016","dateIssuedKey":"2016"}],"recId":"1567278299","person":[{"roleDisplay":"VerfasserIn","given":"Martin","role":"aut","family":"Schmidt-Hieber","display":"Schmidt-Hieber, Martin"},{"role":"aut","given":"Dieter","display":"Buchheidt, Dieter","family":"Buchheidt","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Hähnel","display":"Hähnel, Stefan","given":"Stefan","role":"aut"}],"language":["eng"],"relHost":[{"pubHistory":["1.1990 -"],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"European Society for Medical Oncology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"7","pages":"1207-1225","volume":"27","extent":"19","year":"2016","text":"27(2016), 7, Seite 1207-1225"},"note":["Gesehen am 12.11.20","Ungezählte Beil.: Supplement"],"id":{"zdb":["2003498-2"],"eki":["320428796"],"issn":["1569-8041"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Annals of oncology","subtitle":"official journal of the European Society for Medical Oncology","title":"Annals of oncology"}],"language":["eng"],"origin":[{"dateIssuedKey":"1990","publisher":"Elsevier ; Kluwer ; Oxford Univ. Press","dateIssuedDisp":"1990-","publisherPlace":"Amsterdam [u.a.] ; Dordrecht [u.a.] ; Oxford"}],"disp":"CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation) guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)Annals of oncology","recId":"320428796"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 17.01.2018"],"id":{"eki":["1567278299"],"doi":["10.1093/annonc/mdw155"]},"physDesc":[{"extent":"19 S."}]} | ||
| SRT | |a SCHMIDTHIECNSINFECTI6201 | ||