Buchumschlag

Prospective phase-II-study evaluating postoperative radiotherapy of cervical and endometrial cancer patients using protons - the APROVE-trial

Weitere Versionen anzeigen (1)

The prognosis for patients with cervical or endometrial cancer has improved over the last decades. Thus, reducing therapy-related toxicity and impact on quality of life have become more and more important. With the development of new radiotherapy techniques like IMRT (Intensity-modulated radiotherap...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Arians, Nathalie (VerfasserIn) , Lindel, Katja (VerfasserIn) , Krisam, Johannes (VerfasserIn) , Herfarth, Klaus (VerfasserIn) , Krug, David (VerfasserIn) , Akbaba, Sati (VerfasserIn) , Oelmann-Avendano, Jan Tobias (VerfasserIn) , Debus, Jürgen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 November 2017
In: Radiation oncology
Year: 2017, Jahrgang: 12
ISSN:1748-717X
DOI:10.1186/s13014-017-0926-5
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13014-017-0926-5
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-017-0926-5
Volltext
Verfasserangaben:N. Arians, K. Lindel, J. Krisam, K. Herfarth, D. Krug, S. Akbaba, J. Oelmann-Avendano and J. Debus
Beschreibung
Zusammenfassung:The prognosis for patients with cervical or endometrial cancer has improved over the last decades. Thus, reducing therapy-related toxicity and impact on quality of life have become more and more important. With the development of new radiotherapy techniques like IMRT (Intensity-modulated radiotherapy) the incidence of acute and chronic toxicities has already been reduced. Nevertheless, rates of complications requiring medical treatment range from 0.7-8% according to literature. 7.7% of patients develop severe complications after 5 years with an increasing risk for complications of 0.3%/year. Particularly, the volume of the small and large bowel receiving low doses (15 Gy) has been shown to be a predictive factor for the development of higher bowel toxicity. With the introduction of proton therapy into clinical practice, there are new opportunities for optimization of organ at risk-sparing thus possibly reducing toxicity.
Beschreibung:Gesehen am 18.01.2018
Beschreibung:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-017-0926-5

Ähnliche Einträge