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Activity of immune checkpoint inhibition in platinum refractory germ-cell tumors

© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.The outcome of patients with platinum refractory germ cell cancer who relapse after or are no candidates for...

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Bibliographic Details
Main Authors: Zschäbitz, Stefanie (Author) , Lasitschka, Felix (Author) , Jäger, Dirk (Author) , Grüllich, Carsten (Author)
Format: Article (Journal) Editorial
Language:English
Published: 30 March 2016
In: Annals of oncology
Year: 2016, Volume: 27, Issue: 7, Pages: 1356-1360
ISSN:1569-8041
DOI:10.1093/annonc/mdw146
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1093/annonc/mdw146
Verlag, kostenfrei, Volltext: https://academic.oup.com/annonc/article/27/7/1356/1741225
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Author Notes:S. Zschäbitz, F. Lasitschka, D. Jäger and C. Grüllich
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Summary:© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.The outcome of patients with platinum refractory germ cell cancer who relapse after or are no candidates for stem-cell transplantation is dismal. No significant progress has been made within the last years. The use of anti-PD-1 antibodies has led to complete remissions and long-term disease control in patients with non-small-cell lung cancer, renal cell carcinoma, and malignant melanoma with metastasized disease [1-3]. Recently, PD-L1 expression in testicular germ-cell tumor samples has been described [4, 5]....We report on the clinical course of four heavily pretreated patients with platinum refractory germ-cell tumors for whom no more curative standard existed and who received checkpoint inhibitors (anti-PD-1 antibodies). Detailed characteristics of pretreatment schedules are given in Table 1 (patients 3 and 4)...
Item Description:Gesehen am 19.01.2018
Physical Description:Online Resource
ISSN:1569-8041
DOI:10.1093/annonc/mdw146

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