Activity of immune checkpoint inhibition in platinum refractory germ-cell tumors
© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.The outcome of patients with platinum refractory germ cell cancer who relapse after or are no candidates for...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
30 March 2016
|
| In: |
Annals of oncology
Year: 2016, Jahrgang: 27, Heft: 7, Pages: 1356-1360 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdw146 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1093/annonc/mdw146 Verlag, kostenfrei, Volltext: https://academic.oup.com/annonc/article/27/7/1356/1741225 
|
| Verfasserangaben: | S. Zschäbitz, F. Lasitschka, D. Jäger and C. Grüllich |
| Zusammenfassung: | © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.The outcome of patients with platinum refractory germ cell cancer who relapse after or are no candidates for stem-cell transplantation is dismal. No significant progress has been made within the last years. The use of anti-PD-1 antibodies has led to complete remissions and long-term disease control in patients with non-small-cell lung cancer, renal cell carcinoma, and malignant melanoma with metastasized disease [1-3]. Recently, PD-L1 expression in testicular germ-cell tumor samples has been described [4, 5]....We report on the clinical course of four heavily pretreated patients with platinum refractory germ-cell tumors for whom no more curative standard existed and who received checkpoint inhibitors (anti-PD-1 antibodies). Detailed characteristics of pretreatment schedules are given in Table 1 (patients 3 and 4)... |
|---|---|
| Beschreibung: | Gesehen am 19.01.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdw146 |