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Albizia harveyi: phytochemical profiling, antioxidant, antidiabetic and hepatoprotective activities of the bark extract

Profiling the polyphenols in the methanol extract from the bark of Albizia harveyi was performed by HPLC-PDA-ESI-MS/MS analysis. The phytochemical analysis identified 39 compounds, the majority of them were flavan-3-ol derivatives and condensed tannins. Total phenolic content, determined by the Foli...

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Hauptverfasser: Sobeh, Mansour (VerfasserIn) , Mahmoud, Mona Fouad (VerfasserIn) , Abdelfattah, Mohamed A. O. (VerfasserIn) , El-Beshbishy, Hesham A. (VerfasserIn) , El-Shazly, Assem (VerfasserIn) , Wink, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Medicinal chemistry research
Year: 2017, Jahrgang: 26, Heft: 12, Pages: 3091-3105
ISSN:1554-8120
DOI:10.1007/s00044-017-2005-8
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1007/s00044-017-2005-8
Verlag, Volltext: https://link.springer.com/article/10.1007/s00044-017-2005-8
Volltext
Verfasserangaben:Mansour Sobeh, Mona F. Mahmoud, Mohamed A. O. Abdelfattah, Hesham A. El-Beshbishy, Assem M. El-Shazly, Michael Wink

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520 |a Profiling the polyphenols in the methanol extract from the bark of Albizia harveyi was performed by HPLC-PDA-ESI-MS/MS analysis. The phytochemical analysis identified 39 compounds, the majority of them were flavan-3-ol derivatives and condensed tannins. Total phenolic content, determined by the Folin-Ciocalteu method amounted to 489 mg gallic acid equivalents/g extract. The extract showed promising antioxidant activities with an EC50 of 3.6 µg/mL and 18.32 mM FeSO4 equivalent/mg extract in radical scavenging assay and ferric reducing antioxidant power assays, respectively. The hepatoprotective potential of the extract in rats was determined in vivo in a d-galactosamine-induced liver toxicity model. A dose of 100 mg/kg (body weight) of the bark extract reduced levels of aspartate aminotransferase, gamma-glutamyltransferase and total bilirubin by 35.7, 65.3, and 23.8% (p < 0.05), respectively whereas glutathione was increased by 59.1%. These effects were similar to silymarin which was used as positive control. The extract (100 mg/kg (body weight) mediated a substantial antidiabetic response in streptozotocin-induced diabetic rats manifested by a significant reduction in serum glucose and lipid peroxides and significant increase of serum insulin. Docking of d-(+) catechin and the dimer (epi)catechin-(epi)catechin into the active site of the enzymes human pancreatic α-amylase, maltase-glucoamylase, and aldol reductase revealed that these enzymes may be possible targets via which, the studied Albizia harveyi extract could exert its antidiabetic effect. 
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