HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo
Turraea fischeri is an East African traditional herb, which is widely used in traditional medicine. In this study, we profiled the secondary metabolites in the methanol extract of T. fischeri bark using HPLC-PDA-ESI-MS/MS, and 20 compounds were tentatively identified. Several isomers of the flavonol...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 November 2017
|
| In: |
Molecules
Year: 2017, Jahrgang: 22, Heft: 12 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules22122089 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3390/molecules22122089
|
| Verfasserangaben: | Mansour Sobeh, Mona Mahmoud, Omar Sabry, Rasha Adel, Malak Dmirieh, Assem El Sahzly and Michael Wink |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 156984058X | ||
| 003 | DE-627 | ||
| 005 | 20250114131446.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180214s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/molecules22122089 |2 doi | |
| 035 | |a (DE-627)156984058X | ||
| 035 | |a (DE-576)499840585 | ||
| 035 | |a (DE-599)BSZ499840585 | ||
| 035 | |a (OCoLC)1263963551 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Sobeh, Mansour |e VerfasserIn |0 (DE-588)1099730058 |0 (DE-627)859130444 |0 (DE-576)469346434 |4 aut | |
| 245 | 1 | 0 | |a HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo |c Mansour Sobeh, Mona Mahmoud, Omar Sabry, Rasha Adel, Malak Dmirieh, Assem El Sahzly and Michael Wink |
| 264 | 1 | |c 29 November 2017 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.02.2018 | ||
| 520 | |a Turraea fischeri is an East African traditional herb, which is widely used in traditional medicine. In this study, we profiled the secondary metabolites in the methanol extract of T. fischeri bark using HPLC-PDA-ESI-MS/MS, and 20 compounds were tentatively identified. Several isomers of the flavonolignan cinchonain-I and bis-dihydroxyphenylpropanoid-substituted catechin hexosides dominated the extract. Robust in vitro and in vivo antioxidant properties were observed in 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay (DPPH) and ferric reducing antioxidant power (FRAP) assay, and in the model organism Caenorhabditis elegans. Additionally, the extract exhibited promising hepatoprotective activities in D-galactosamine (D-GaIN) treated rats. A significant reduction in the elevated levels of aspartate aminotransferase (AST), total bilirubin, gamma-glutamyltransferase (GGT), and malondialdehyde (MDA) and increase of glutathione (GSH) was observed in rats treated with the bark extract in addition to D-galactosamine when compared with rats treated with D-galactosamine alone. In conclusion, T. fischeri is apromising candidate for health-promoting and for pharmaceutical applications. | ||
| 700 | 1 | |a Mahmoud, Mona Fouad |e VerfasserIn |0 (DE-588)1067591397 |0 (DE-627)818992468 |0 (DE-576)426773497 |4 aut | |
| 700 | 1 | |a Sabry, Omar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Adel, Rasha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dmirieh, Malak |d 1985- |e VerfasserIn |0 (DE-588)1153030705 |0 (DE-627)1014406587 |0 (DE-576)499840305 |4 aut | |
| 700 | 1 | |a El Sahzly, Assem |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wink, Michael |d 1951- |e VerfasserIn |0 (DE-588)124618146 |0 (DE-627)363448519 |0 (DE-576)164659390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecules |d Basel : MDPI, 1996 |g 22(2017,22) Artikel-Nummer 2089, 14 Seiten |h Online-Ressource |w (DE-627)311313132 |w (DE-600)2008644-1 |w (DE-576)281192456 |x 1420-3049 |7 nnas |a HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo |
| 773 | 1 | 8 | |g volume:22 |g year:2017 |g number:12 |g extent:14 |a HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo |
| 787 | 0 | 8 | |i Errata |a Sobeh, Mansour |t Correction: HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo |d 2024 |w (DE-627)1914551869 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/molecules22122089 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180214 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 124618146 |a Wink, Michael |m 124618146:Wink, Michael |d 160000 |d 160100 |d 700000 |d 729400 |e 160000PW124618146 |e 160100PW124618146 |e 700000PW124618146 |e 729400PW124618146 |k 0/160000/ |k 1/160000/160100/ |k 0/700000/ |k 1/700000/729400/ |p 7 |y j | ||
| 998 | |g 1153030705 |a Dmirieh, Malak |m 1153030705:Dmirieh, Malak |d 160000 |d 160100 |e 160000PD1153030705 |e 160100PD1153030705 |k 0/160000/ |k 1/160000/160100/ |p 5 | ||
| 998 | |g 1099730058 |a Sobeh, Mansour |m 1099730058:Sobeh, Mansour |d 160000 |d 160100 |e 160000PS1099730058 |e 160100PS1099730058 |k 0/160000/ |k 1/160000/160100/ |p 1 |x j | ||
| 999 | |a KXP-PPN156984058X |e 2999307675 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"14 S."}],"name":{"displayForm":["Mansour Sobeh, Mona Mahmoud, Omar Sabry, Rasha Adel, Malak Dmirieh, Assem El Sahzly and Michael Wink"]},"note":["Gesehen am 14.02.2018"],"origin":[{"dateIssuedDisp":"29 November 2017","dateIssuedKey":"2017"}],"language":["eng"],"title":[{"title_sort":"HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo","title":"HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivo"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Mansour","family":"Sobeh","roleDisplay":"VerfasserIn","display":"Sobeh, Mansour","role":"aut"},{"family":"Mahmoud","given":"Mona Fouad","roleDisplay":"VerfasserIn","display":"Mahmoud, Mona Fouad","role":"aut"},{"display":"Sabry, Omar","role":"aut","given":"Omar","family":"Sabry","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","given":"Rasha","family":"Adel","role":"aut","display":"Adel, Rasha"},{"role":"aut","display":"Dmirieh, Malak","roleDisplay":"VerfasserIn","family":"Dmirieh","given":"Malak"},{"family":"El Sahzly","given":"Assem","roleDisplay":"VerfasserIn","display":"El Sahzly, Assem","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Michael","family":"Wink","role":"aut","display":"Wink, Michael"}],"relHost":[{"language":["eng"],"origin":[{"publisherPlace":"Basel","publisher":"MDPI","dateIssuedDisp":"1996-","dateIssuedKey":"1996"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 25.06.20"],"name":{"displayForm":["Molecular Diversity Preservation International"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"311313132","title":[{"subtitle":"a journal of synthetic chemistry and natural product chemistry","title_sort":"Molecules","title":"Molecules"}],"pubHistory":["1.1996 -"],"disp":"HPLC-PDA-MS/MS characterization of bioactive secondary metabolites from Turraea fischeri bark extract and its antioxidant and hepatoprotective activities in vivoMolecules","part":{"extent":"14","issue":"12","year":"2017","volume":"22","text":"22(2017,22) Artikel-Nummer 2089, 14 Seiten"},"id":{"eki":["311313132"],"issn":["1420-3049"],"zdb":["2008644-1"]}}],"recId":"156984058X","id":{"eki":["156984058X"],"doi":["10.3390/molecules22122089"]}} | ||
| SRT | |a SOBEHMANSOHPLCPDAMSM2920 | ||