18F-FDG PET/CT for initial staging in breast cancer patients: Is there a relevant impact on treatment planning compared to conventional staging modalities?
Objective: To evaluate the impact of whole-body 18 F-FDG PET/CT on initial staging of breast cancer in comparison to conventional staging modalities. Methods: This study included 102 breast cancer patients, 101 patients were eligible for evaluation. Preoperative whole-body staging with PET/CT was pe...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 February 2015
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| In: |
European radiology
Year: 2015, Jahrgang: 25, Heft: 8, Pages: 2460-2469 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-015-3630-6 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00330-015-3630-6 Verlag, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00330-015-3630-6 
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| Verfasserangaben: | J. Krammer, A. Schnitzer, C.G. Kaiser, K.A. Buesing, E. Sperk, J. Brade, S. Wasgindt, M. Suetterlin, S.O. Schoenberg, E.J. Sutton, K. Wasser |
| Zusammenfassung: | Objective: To evaluate the impact of whole-body 18 F-FDG PET/CT on initial staging of breast cancer in comparison to conventional staging modalities. Methods: This study included 102 breast cancer patients, 101 patients were eligible for evaluation. Preoperative whole-body staging with PET/CT was performed in patients with clinical stage ≥ T2 tumours or positive local lymph nodes (n = 91). Postoperative PET/CT was performed in patients without these criteria but positive sentinel lymph node biopsy (n = 10). All patients underwent PET/CT and a conventional staging algorithm, which included bone scan, chest X-ray and abdominal ultrasound. PET/CT findings were compared to conventional staging and the impact on therapeutic management was evaluated. Results: PET/CT led to an upgrade of the N or M stage in overall 19 patients (19 %) and newly identified manifestation of breast cancer in two patients (2 %). PET/CT findings caused a change in treatment of 11 patients (11 %). This is within the range of recent studies, all applying conventional inclusion criteria based on the initial T and N status. Conclusions: PET/CT has a relevant impact on initial staging and treatment of breast cancer when compared to conventional modalities. Further studies should assess inclusion criteria beyond the conventional T and N status, e.g. tumour grading and receptor status. |
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| Beschreibung: | Gesehen am 19.02.2018 Im Titel ist "18" hochgestellt |
| Beschreibung: | Online Resource |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-015-3630-6 |