Thymoma related myasthenia gravis in humans and potential animal models
Thymoma-associated Myasthenia gravis (TAMG) is one of the anti-acetylcholine receptor MG (AChR-MG) subtypes. The clinico-pathological features of TAMG and its pathogenesis are described here in comparison with pathogenetic models suggested for the more common non-thymoma AChR-MG subtypes, early onse...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 2015
|
| In: |
Experimental neurology
Year: 2015, Jahrgang: 270, Pages: 55-65 |
| ISSN: | 1090-2430 |
| DOI: | 10.1016/j.expneurol.2015.02.010 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.expneurol.2015.02.010 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0014488615000333 
|
| Verfasserangaben: | Alexander Marx, Stefan Porubsky, Djeda Belharazem, Güher Saruhan-Direskeneli, Berthold Schalke, Philipp Ströbel, Cleo-Aron Weis |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1569956812 | ||
| 003 | DE-627 | ||
| 005 | 20220814075531.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180219s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.expneurol.2015.02.010 |2 doi | |
| 035 | |a (DE-627)1569956812 | ||
| 035 | |a (DE-576)499956818 | ||
| 035 | |a (DE-599)BSZ499956818 | ||
| 035 | |a (OCoLC)1340987477 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Marx, Alexander |d 1956- |e VerfasserIn |0 (DE-588)122478258 |0 (DE-627)705923673 |0 (DE-576)214254488 |4 aut | |
| 245 | 1 | 0 | |a Thymoma related myasthenia gravis in humans and potential animal models |c Alexander Marx, Stefan Porubsky, Djeda Belharazem, Güher Saruhan-Direskeneli, Berthold Schalke, Philipp Ströbel, Cleo-Aron Weis |
| 264 | 1 | |c August 2015 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.02.2018 | ||
| 520 | |a Thymoma-associated Myasthenia gravis (TAMG) is one of the anti-acetylcholine receptor MG (AChR-MG) subtypes. The clinico-pathological features of TAMG and its pathogenesis are described here in comparison with pathogenetic models suggested for the more common non-thymoma AChR-MG subtypes, early onset MG and late onset MG. Emphasis is put on the role of abnormal intratumorous T cell selection and activation, lack of intratumorous myoid cells and regulatory T cells as well as deficient expression of the autoimmune regulator (AIRE) by neoplastic thymic epithelial cells. We review spontaneous and genetically engineered thymoma models in a spectrum of animals and the extensive clinical and immunological overlap between canine, feline and human TAMG. Finally, limitations and perspectives of the transplantation of human and murine thymoma tissue into nude mice, as potential models for TAMG, are addressed. | ||
| 650 | 4 | |a AIRE | |
| 650 | 4 | |a Animal model | |
| 650 | 4 | |a APS-I | |
| 650 | 4 | |a BUF/Mna | |
| 650 | 4 | |a Cat | |
| 650 | 4 | |a Dog | |
| 650 | 4 | |a Horse | |
| 650 | 4 | |a Myasthenia gravis | |
| 650 | 4 | |a Rat | |
| 650 | 4 | |a Thymoma | |
| 650 | 4 | |a Tiger | |
| 700 | 1 | |a Porubský, Štefan |d 1977- |e VerfasserIn |0 (DE-588)12958844X |0 (DE-627)473362341 |0 (DE-576)29773637X |4 aut | |
| 700 | 1 | |a Belharazem, Djeda |d 1975- |e VerfasserIn |0 (DE-588)132387522 |0 (DE-627)52195276X |0 (DE-576)299114252 |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Experimental neurology |d Amsterdam [u.a.] : Elsevier, 1959 |g 270(2015), Seite 55-65 |h Online-Ressource |w (DE-627)266018106 |w (DE-600)1466932-8 |w (DE-576)106845926 |x 1090-2430 |7 nnas |a Thymoma related myasthenia gravis in humans and potential animal models |
| 773 | 1 | 8 | |g volume:270 |g year:2015 |g pages:55-65 |g extent:11 |a Thymoma related myasthenia gravis in humans and potential animal models |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.expneurol.2015.02.010 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0014488615000333 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180219 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ |p 7 |y j | ||
| 998 | |g 132387522 |a Belharazem, Djeda |m 132387522:Belharazem, Djeda |d 60000 |d 63400 |e 60000PB132387522 |e 63400PB132387522 |k 0/60000/ |k 1/60000/63400/ |p 3 | ||
| 998 | |g 12958844X |a Porubský, Štefan |m 12958844X:Porubský, Štefan |d 60000 |d 63400 |e 60000PP12958844X |e 63400PP12958844X |k 0/60000/ |k 1/60000/63400/ |p 2 | ||
| 998 | |g 122478258 |a Marx, Alexander |m 122478258:Marx, Alexander |d 60000 |d 63400 |e 60000PM122478258 |e 63400PM122478258 |k 0/60000/ |k 1/60000/63400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1569956812 |e 299960307X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Thymoma related myasthenia gravis in humans and potential animal models","title":"Thymoma related myasthenia gravis in humans and potential animal models"}],"relHost":[{"id":{"issn":["1090-2430"],"zdb":["1466932-8"],"eki":["266018106"]},"recId":"266018106","physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1959 -"],"note":["Gesehen am 05.02.20"],"disp":"Thymoma related myasthenia gravis in humans and potential animal modelsExperimental neurology","part":{"year":"2015","text":"270(2015), Seite 55-65","extent":"11","pages":"55-65","volume":"270"},"language":["eng"],"title":[{"subtitle":"a journal of neuroscience research","title_sort":"Experimental neurology","title":"Experimental neurology"}],"origin":[{"publisher":"Elsevier ; Academic Press","dateIssuedDisp":"1959-","dateIssuedKey":"1959","publisherPlace":"Amsterdam [u.a.] ; Orlando, Fla."}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"August 2015"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.expneurol.2015.02.010"],"eki":["1569956812"]},"recId":"1569956812","physDesc":[{"extent":"11 S."}],"note":["Gesehen am 19.02.2018"],"person":[{"display":"Marx, Alexander","role":"aut","roleDisplay":"VerfasserIn","family":"Marx","given":"Alexander"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Porubský, Štefan","given":"Štefan","family":"Porubský"},{"family":"Belharazem","given":"Djeda","roleDisplay":"VerfasserIn","display":"Belharazem, Djeda","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Weis, Cleo-Aron Thias","role":"aut","given":"Cleo-Aron Thias","family":"Weis"}],"name":{"displayForm":["Alexander Marx, Stefan Porubsky, Djeda Belharazem, Güher Saruhan-Direskeneli, Berthold Schalke, Philipp Ströbel, Cleo-Aron Weis"]}} | ||
| SRT | |a MARXALEXANTHYMOMAREL2015 | ||