Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo
45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 June 2016
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| In: |
Journal of materials science
Year: 2016, Jahrgang: 27, Heft: 7, Pages: 119 |
| ISSN: | 1573-4838 |
| DOI: | 10.1007/s10856-016-5732-3 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s10856-016-5732-3 Verlag, Volltext: https://link.springer.com/article/10.1007/s10856-016-5732-3 
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| Verfasserangaben: | Fabian Westhauser, Christian Weis, Matthäus Prokscha, Leonie A. Bittrich, Wei Li, Kai Xiao, Ulrich Kneser, Hans-Ulrich Kauczor, Gerhard Schmidmaier, Aldo R. Boccaccini, Arash Moghaddam |
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| 520 | |a 45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D-45S5 bioactive glass (BG) scaffolds seeded with human mesenchymal stem cells (hMSC) in vivo. BG scaffolds coated with gelatin, cross-linked gelatin, and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were seeded with hMSC prior to implantation into severe combined immunodeficiency mice. Newly formed bone was evaluated with histomorphometry and micro-computed tomography. Bone formation was detectable in all groups, whereas the gelatin-coated BG scaffolds showed the best results and should be considered in further studies.Graphical Abstract Open image in new window | ||
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