Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma
Background: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular carcinoma (HCC). It has been reported that the anti-cancer drug 5-azacytidine (5-AZA) mediates the activation of tumor suppressor genes through passive demethylation by inhibiting DNMT1. Recent evidenc...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 September 2015
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| In: |
Clinical epigenetics
Year: 2015, Jahrgang: 7 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-015-0133-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13148-015-0133-x Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-015-0133-x 
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| Verfasserangaben: | Sahar Olsadat Sajadian, Sabrina Ehnert, Haghighat Vakilian, Eirini Koutsouraki, Georg Damm, Daniel Seehofer, Wolfgang Thasler, Steven Dooley, Hossein Baharvand, Bence Sipos and Andreas K. Nussler |
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Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma
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