Does comorbid disruptive behavior modify the effects of atomoxetine on ADHD symptoms as measured by a continuous performance test and a motion tracking device?
Objective: To compare the reduction of ADHD symptoms under atomoxetine in patients with and without comorbid oppositional defiant disorder (ODD) or conduct disorder (CD) using a computer-based continuous performance test (cb-CPT) combined with an infrared motion tracking (MT) device. Method: Seconda...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| In: |
Journal of attention disorders
Year: 2015, Jahrgang: 19, Heft: 7, Pages: 591-602 |
| ISSN: | 1557-1246 |
| DOI: | 10.1177/1087054712456739 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1177/1087054712456739 Verlag, Volltext: https://doi.org/10.1177/1087054712456739 
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| Verfasserangaben: | Peter M. Wehmeier, Laura Kipp, Tobias Banaschewski, Ralf W. Dittmann, and Alexander Schacht |
MARC
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| 245 | 1 | 0 | |a Does comorbid disruptive behavior modify the effects of atomoxetine on ADHD symptoms as measured by a continuous performance test and a motion tracking device? |c Peter M. Wehmeier, Laura Kipp, Tobias Banaschewski, Ralf W. Dittmann, and Alexander Schacht |
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| 520 | |a Objective: To compare the reduction of ADHD symptoms under atomoxetine in patients with and without comorbid oppositional defiant disorder (ODD) or conduct disorder (CD) using a computer-based continuous performance test (cb-CPT) combined with an infrared motion tracking (MT) device. Method: Secondary analysis of a placebo-controlled study in ADHD patients (6-12 years old) treated with atomoxetine (target dose: 1.2 mg/kg per day). Cb-CPT/MT scores were analyzed using ANCOVA (last observation carried forward [LOCF]). Results: The data (N = 125) suggested a more pronounced atomoxetine effect in the group with comorbid ODD/CD as measured by all cb-CPT/MT parameters except for “normalized variation of reaction time” (nVRT). Conclusion: The results showed that atomoxetine reduced ADHD severity as measured by cb-CPT and MT parameters regardless of whether comorbid ODD/CD was present. The treatment effect of atomoxetine on hyperactivity appears to be more pronounced in the subgroup of patients with comorbid ODD/CD than in the subgroup without this comorbidity. | ||
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