Junb controls lymphatic vascular development in zebrafish via miR-182
JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, infl...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 October 2015
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| In: |
Scientific reports
Year: 2015, Jahrgang: 5 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep15007 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/srep15007 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/srep15007 
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| Verfasserangaben: | Kristin Kiesow, Katrin Bennewitz, Laura Gutierrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll, Marina Schorpp-Kistner |
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| 520 | |a JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as well as a negative regulator of proliferation, inflammation and tumour growth. Here, we demonstrate that the oncogenic miR-182 is a novel JUNB target. Loss-of-function studies by morpholino-mediated knockdown and the CRISPR/Cas9 technology identify a novel function for both JUNB and its target miR-182 in lymphatic vascular development in zebrafish. Furthermore, we show that miR-182 attenuates foxo1 expression indicating that strictly balanced Foxo1 levels are required for proper lymphatic vascular development in zebrafish. In conclusion, our findings uncover with the Junb/miR-182/Foxo1 regulatory axis a novel key player in governing lymphatic vascular morphogenesis in zebrafish. | ||
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