Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes
Summary The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1 diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia. From analogy to T1D, insulin resistance and hyperglycemia are thought to also play causal roles in T2D. Recent clinical...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 March 2018
|
| In: |
Cell metabolism
Year: 2018, Volume: 27, Issue: 4 |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2018.02.003 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.cmet.2018.02.003 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1550413118301141 
|
| Author Notes: | Alexandra Moraru, Janica Wiederstein, Daniel Pfaff, Thomas Fleming, Aubry K. Miller, Peter Nawroth, Aurelio A. Teleman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571426388 | ||
| 003 | DE-627 | ||
| 005 | 20240316100331.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180326s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cmet.2018.02.003 |2 doi | |
| 035 | |a (DE-627)1571426388 | ||
| 035 | |a (DE-576)501426388 | ||
| 035 | |a (DE-599)BSZ501426388 | ||
| 035 | |a (OCoLC)1340995575 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Moraru, Alexandra |e VerfasserIn |0 (DE-588)1117114619 |0 (DE-627)871034050 |0 (DE-576)478768621 |4 aut | |
| 245 | 1 | 0 | |a Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes |c Alexandra Moraru, Janica Wiederstein, Daniel Pfaff, Thomas Fleming, Aubry K. Miller, Peter Nawroth, Aurelio A. Teleman |
| 264 | 1 | |c 15 March 2018 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.04.2022 | ||
| 520 | |a Summary The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1 diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia. From analogy to T1D, insulin resistance and hyperglycemia are thought to also play causal roles in T2D. Recent clinical studies, however, found that T2D patients treated to maintain glycemia below the diabetes definition threshold (HbA1c < 6.5%) still develop diabetic complications. This suggests additional insulin- and glucose-independent mechanisms could be involved in T2D progression and/or initiation. T2D patients have elevated levels of the metabolite methylglyoxal (MG). We show here, using Drosophila glyoxalase 1 knockouts, that animals with elevated methylglyoxal recapitulate several core aspects of T2D: insulin resistance, obesity, and hyperglycemia. Thus elevated MG could constitute one root cause of T2D, suggesting that the molecular causes of elevated MG warrant further study. | ||
| 650 | 4 | |a Drosophila | |
| 650 | 4 | |a Glo1 | |
| 650 | 4 | |a methylglyoxal | |
| 700 | 1 | |a Pfaff, Daniel |d 1984- |e VerfasserIn |0 (DE-588)1155117859 |0 (DE-627)1016369255 |0 (DE-576)501432051 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
| 700 | 1 | |a Nawroth, Peter Paul |d 1954- |e VerfasserIn |0 (DE-588)1020504897 |0 (DE-627)69123941X |0 (DE-576)360517692 |4 aut | |
| 700 | 1 | |a Teleman, Aurelio A. |d 1976- |e VerfasserIn |0 (DE-588)1155118294 |0 (DE-627)1016370121 |0 (DE-576)501431861 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell metabolism |d Amsterdam [u.a.] : Elsevier, 2005 |g 27(2018,4) S. 926-934, e1-e8, 17 Seiten |h Online-Ressource |w (DE-627)477987451 |w (DE-600)2174469-5 |w (DE-576)252254643 |x 1932-7420 |7 nnas |a Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes |
| 773 | 1 | 8 | |g volume:27 |g year:2018 |g number:4 |g extent:17 |a Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.cmet.2018.02.003 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1550413118301141 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180326 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1155118294 |a Teleman, Aurelio A. |m 1155118294:Teleman, Aurelio A. |d 140000 |e 140000PT1155118294 |k 0/140000/ |p 7 |y j | ||
| 998 | |g 1020504897 |a Nawroth, Peter Paul |m 1020504897:Nawroth, Peter Paul |d 910000 |d 910100 |e 910000PN1020504897 |e 910100PN1020504897 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1034445294 |a Fleming, Thomas |m 1034445294:Fleming, Thomas |d 910000 |d 910100 |e 910000PF1034445294 |e 910100PF1034445294 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1155117859 |a Pfaff, Daniel |m 1155117859:Pfaff, Daniel |d 910000 |d 910100 |e 910000PP1155117859 |e 910100PP1155117859 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 999 | |a KXP-PPN1571426388 |e 3004308924 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Moraru","display":"Moraru, Alexandra","roleDisplay":"VerfasserIn","role":"aut","given":"Alexandra"},{"family":"Pfaff","display":"Pfaff, Daniel","role":"aut","roleDisplay":"VerfasserIn","given":"Daniel"},{"family":"Fleming","given":"Thomas","role":"aut","roleDisplay":"VerfasserIn","display":"Fleming, Thomas"},{"display":"Nawroth, Peter Paul","role":"aut","roleDisplay":"VerfasserIn","given":"Peter Paul","family":"Nawroth"},{"family":"Teleman","display":"Teleman, Aurelio A.","given":"Aurelio A.","role":"aut","roleDisplay":"VerfasserIn"}],"language":["eng"],"origin":[{"dateIssuedDisp":"15 March 2018","dateIssuedKey":"2018"}],"name":{"displayForm":["Alexandra Moraru, Janica Wiederstein, Daniel Pfaff, Thomas Fleming, Aubry K. Miller, Peter Nawroth, Aurelio A. Teleman"]},"id":{"eki":["1571426388"],"doi":["10.1016/j.cmet.2018.02.003"]},"physDesc":[{"extent":"17 S."}],"relHost":[{"disp":"Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetesCell metabolism","language":["eng"],"origin":[{"dateIssuedDisp":"2005-","publisher":"Elsevier ; Cell Press","publisherPlace":"Amsterdam [u.a.] ; Cambridge, Mass.","dateIssuedKey":"2005"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Cell metabolism","title_sort":"Cell metabolism"}],"id":{"issn":["1932-7420"],"zdb":["2174469-5"],"eki":["477987451"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2005 -"],"recId":"477987451","part":{"year":"2018","extent":"17","text":"27(2018,4) S. 926-934, e1-e8, 17 Seiten","issue":"4","volume":"27"},"note":["Gesehen am 24.04.25"]}],"title":[{"title":"Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes","title_sort":"Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 dffiabetes"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.04.2022"],"recId":"1571426388"} | ||
| SRT | |a MORARUALEXELEVATEDLE1520 | ||