Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain: a 1H MRS study of healthy subjects
ObjectiveIt has previously been reported that even social alcohol consumption affects the magnetic resonance spectroscopy (MRS) signals of choline-containing compounds (tCho). The purpose of this study was to investigate whether the consumption of alcohol affects the concentrations of the metabolite...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 May 2015
|
| In: |
Magnetic resonance materials in physics, biology and medicine
Year: 2015, Jahrgang: 28, Heft: 5, Pages: 503-510 |
| ISSN: | 1352-8661 |
| DOI: | 10.1007/s10334-015-0486-3 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s10334-015-0486-3 Verlag, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s10334-015-0486-3 
|
| Verfasserangaben: | Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Gabriele Ende |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 157145425X | ||
| 003 | DE-627 | ||
| 005 | 20230428184854.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180327s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10334-015-0486-3 |2 doi | |
| 035 | |a (DE-627)157145425X | ||
| 035 | |a (DE-576)50145425X | ||
| 035 | |a (DE-599)BSZ50145425X | ||
| 035 | |a (OCoLC)1340995775 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tunç-Skarka, Nuran |d 1979- |e VerfasserIn |0 (DE-588)143385801 |0 (DE-627)645142565 |0 (DE-576)336789319 |4 aut | |
| 245 | 1 | 0 | |a Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain |b a 1H MRS study of healthy subjects |c Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Gabriele Ende |
| 246 | 3 | 3 | |a Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain$da 1 H MRS study of healthy subjects |
| 264 | 1 | |c 16 May 2015 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.03.2018 | ||
| 500 | |a Die Zahl 1 im Titel ist hochgestellt | ||
| 520 | |a ObjectiveIt has previously been reported that even social alcohol consumption affects the magnetic resonance spectroscopy (MRS) signals of choline-containing compounds (tCho). The purpose of this study was to investigate whether the consumption of alcohol affects the concentrations of the metabolites tCho, N-acetylaspartate, creatine, or myo-inositol and/or their T 2 relaxation times.Materials and methods 1H MR spectra were obtained at 3 T from a frontal white matter voxel of 25 healthy subjects with social alcohol consumption (between 0 and 25.9 g/day). Absolute brain metabolite concentrations and T 2 relaxation times of metabolites were examined via MRS measurements at different echo times. Metabolite concentrations and their T 2 relaxation times were correlated with subjects’ alcohol consumption, controlling for age.ResultsWe observed positive correlations of absolute tCho and phosphocreatine and creatine (tCr) concentrations with alcohol consumption but no correlation between any metabolite T 2 relaxation time and alcohol consumption.ConclusionsThis study shows that even social alcohol consumption affects the concentrations of tCho and tCr in cerebral white matter. Future studies assessing brain tCho and tCr levels should control for the confounding factor alcohol consumption. | ||
| 700 | 1 | |a Weber-Fahr, Wolfgang |d 1968- |e VerfasserIn |0 (DE-588)115518291X |0 (DE-627)1016515316 |0 (DE-576)501454578 |4 aut | |
| 700 | 1 | |a Ende, Gabriele |e VerfasserIn |0 (DE-588)1031974105 |0 (DE-627)737671734 |0 (DE-576)379696886 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Magnetic resonance materials in physics, biology and medicine |d Heidelberg : Springer, 1993 |g 28(2015), 5, Seite 503-510 |h Online-Ressource |w (DE-627)308449711 |w (DE-600)1502491-X |w (DE-576)113948557 |x 1352-8661 |7 nnas |a Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain a 1H MRS study of healthy subjects |
| 773 | 1 | 8 | |g volume:28 |g year:2015 |g number:5 |g pages:503-510 |g extent:8 |a Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain a 1H MRS study of healthy subjects |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10334-015-0486-3 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s10334-015-0486-3 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180327 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1031974105 |a Ende, Gabriele |m 1031974105:Ende, Gabriele |d 60000 |e 60000PE1031974105 |k 0/60000/ |p 3 |y j | ||
| 998 | |g 115518291X |a Weber-Fahr, Wolfgang |m 115518291X:Weber-Fahr, Wolfgang |d 60000 |e 60000PW115518291X |k 0/60000/ |p 2 | ||
| 999 | |a KXP-PPN157145425X |e 3004346850 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 27.03.2018","Die Zahl 1 im Titel ist hochgestellt"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"subtitle":"a 1H MRS study of healthy subjects","title":"Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain","title_sort":"Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain"}],"person":[{"family":"Tunç-Skarka","role":"aut","given":"Nuran","display":"Tunç-Skarka, Nuran"},{"family":"Weber-Fahr","role":"aut","given":"Wolfgang","display":"Weber-Fahr, Wolfgang"},{"display":"Ende, Gabriele","family":"Ende","given":"Gabriele","role":"aut"}],"relHost":[{"corporate":[{"role":"isb","display":"European Society of Magnetic Resonance in Medicine and Biology"}],"pubHistory":["1.1993 -"],"titleAlt":[{"title":"Magma"},{"title":"Magma"}],"id":{"zdb":["1502491-X"],"issn":["1352-8661"],"eki":["308449711"]},"part":{"volume":"28","year":"2015","text":"28(2015), 5, Seite 503-510","extent":"8","issue":"5","pages":"503-510"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"308449711","disp":"Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain a 1H MRS study of healthy subjectsMagnetic resonance materials in physics, biology and medicine","origin":[{"publisher":"Springer ; Elsevier Science","dateIssuedDisp":"1993-","dateIssuedKey":"1993","publisherPlace":"Heidelberg ; Amsterdam [u.a.]"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 18.10.05","Ungezählte Beil.: Supplement"],"title":[{"title_sort":"Magnetic resonance materials in physics, biology and medicine","title":"Magnetic resonance materials in physics, biology and medicine","subtitle":"(MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB)"}]}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"16 May 2015"}],"physDesc":[{"extent":"8 S."}],"recId":"157145425X","id":{"eki":["157145425X"],"doi":["10.1007/s10334-015-0486-3"]},"titleAlt":[{"title":"Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain$da 1 H MRS study of healthy subjects"}],"name":{"displayForm":["Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Gabriele Ende"]}} | ||
| SRT | |a TUNCSKARKARECREATION1620 | ||