Specificities of ischemic stroke risk factors in Arab-speaking countries
<b><i>Background:</i></b> Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. <b><i>Summary:</i></b> We perform...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 15, 2017
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| In: |
Cerebrovascular diseases
Year: 2017, Volume: 43, Issue: 3/4, Pages: 169-177 |
| ISSN: | 1421-9786 |
| DOI: | 10.1159/000454776 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1159/000454776 Verlag, Volltext: https://www-karger-com.ezproxy.medma.uni-heidelberg.de/Article/FullText/454776 
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| Author Notes: | Halim Abboud, Leila Sissani, Julien Labreuche, Antonio Arauz, Marie-Germaine Bousser, Alain Bryer, Angel Chamorro, Marc Fisher, Ian Ford, Kim M. Fox, Michael G. Hennerici, Pablo M. Lavados, Ayrton Massaro, Heinrich P. Mattle, Mario Munoz Collazos, Peter M. Rothwell, Philippe Gabriel Steg, Eric Vicaut, Bassem Yamouth, Pierre Amarenco, on behalf of the OPTIC Registry and PERFORM Trial Investigators |
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| 520 | |a <b><i>Background:</i></b> Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. <b><i>Summary:</i></b> We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (<i>n</i> = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both <i>p </i>≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; <i>p </i>= 0.07). <b><i>Key Messages:</i></b> Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level. | ||
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