The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration
Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN). Additionally...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 May 2017
|
| In: |
Journal of diabetes research
Year: 2017, Jahrgang: 2017 |
| ISSN: | 2314-6753 |
| DOI: | 10.1155/2017/9506730 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2017/9506730 Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/jdr/2017/9506730/ 
|
| Verfasserangaben: | Thomas Albrecht, Shiqi Zhang, Jana D. Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P. Schmitt, Jacob van den Born, Stephan J. L. Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K. Krämer, Benito A. Yard, and Sibylle J. Hauske |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 157154383X | ||
| 003 | DE-627 | ||
| 005 | 20220814103056.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180329s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2017/9506730 |2 doi | |
| 035 | |a (DE-627)157154383X | ||
| 035 | |a (DE-576)50154383X | ||
| 035 | |a (DE-599)BSZ50154383X | ||
| 035 | |a (OCoLC)1341000096 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Albrecht, Thomas |d 1989- |e VerfasserIn |0 (DE-588)1155320581 |0 (DE-627)1016731574 |0 (DE-576)501542779 |4 aut | |
| 245 | 1 | 4 | |a The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration |c Thomas Albrecht, Shiqi Zhang, Jana D. Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P. Schmitt, Jacob van den Born, Stephan J. L. Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K. Krämer, Benito A. Yard, and Sibylle J. Hauske |
| 264 | 1 | |c 3 May 2017 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.03.2018 | ||
| 520 | |a Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN). Additionally, it assessed if the prevalence of the protective genotype changes with diabetes duration and time on hemodialysis and if this occurs in association with serum carnosinase (CN-1) activity. Whereas the distribution of the (CTG)5 homozygous genotype in the no-DN and CIC-DN patients was comparable, a lower frequency was found in the BP-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis. This was also observed for diabetes duration but only reached significance when both (CTG)5 homo- and heterozygous patients were included. CN-1 activity negatively correlated with time on hemodialysis and was lower in (CTG)5 homozygous patients. The latter remained significant in female subjects after gender stratification. We confirm the association between the CNDP1 genotype and DN to be likely gender-specific. Although our data also suggest that (CTG)5 homozygous patients may have a survival advantage on dialysis and in diabetes, this hypothesis needs to be confirmed in a prospective cohort study. | ||
| 700 | 1 | |a Braun, Jana D. |d 1991- |e VerfasserIn |0 (DE-588)1155321103 |0 (DE-627)1016732082 |0 (DE-576)501543074 |4 aut | |
| 700 | 1 | |a Qiu, Jiedong |d 1991- |e VerfasserIn |0 (DE-588)1155321650 |0 (DE-627)1016732619 |0 (DE-576)501543775 |4 aut | |
| 700 | 1 | |a Peters, Verena |d 1968- |e VerfasserIn |0 (DE-588)118132202 |0 (DE-627)69469892X |0 (DE-576)291731848 |4 aut | |
| 700 | 1 | |a Schmitt, Claus P. |e VerfasserIn |0 (DE-588)1030179123 |0 (DE-627)734893620 |0 (DE-576)377990280 |4 aut | |
| 700 | 1 | |a Lammert, Alexander |d 1975- |e VerfasserIn |0 (DE-588)129092738 |0 (DE-627)389525898 |0 (DE-576)188420983 |4 aut | |
| 700 | 1 | |a Köppel, Hannes |d 1972- |e VerfasserIn |0 (DE-588)124090273 |0 (DE-627)706534107 |0 (DE-576)294015809 |4 aut | |
| 700 | 1 | |a Schnülle, Peter |d 1957- |e VerfasserIn |0 (DE-588)1028873905 |0 (DE-627)731785282 |0 (DE-576)376314907 |4 aut | |
| 700 | 1 | |a Krämer, Bernhard |d 1957- |e VerfasserIn |0 (DE-588)14017589X |0 (DE-627)70358927X |0 (DE-576)314926852 |4 aut | |
| 700 | 1 | |a Yard, Benito A. |d 1961- |e VerfasserIn |0 (DE-588)1025110633 |0 (DE-627)721145892 |0 (DE-576)369951735 |4 aut | |
| 700 | 1 | |a Hauske, Sibylle J. |d 1976-2025 |e VerfasserIn |0 (DE-588)137856253 |0 (DE-627)596151527 |0 (DE-576)305349686 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of diabetes research |d [Hoboken, NJ] : Wiley, 2013 |g 2017(2017) Artikel-Nummer 9506730, 11 Seiten |h Online-Ressource |w (DE-627)742225437 |w (DE-600)2711897-6 |w (DE-576)381276260 |x 2314-6753 |7 nnas |a The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration |
| 773 | 1 | 8 | |g volume:2017 |g year:2017 |g extent:11 |a The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1155/2017/9506730 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/jdr/2017/9506730/ |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180329 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 137856253 |a Hauske, Sibylle J. |m 137856253:Hauske, Sibylle J. |d 60000 |d 61400 |e 60000PH137856253 |e 61400PH137856253 |k 0/60000/ |k 1/60000/61400/ |p 16 |y j | ||
| 998 | |g 1025110633 |a Yard, Benito A. |m 1025110633:Yard, Benito A. |d 60000 |d 61400 |e 60000PY1025110633 |e 61400PY1025110633 |k 0/60000/ |k 1/60000/61400/ |p 15 | ||
| 998 | |g 14017589X |a Krämer, Bernhard |m 14017589X:Krämer, Bernhard |d 60000 |d 61400 |e 60000PK14017589X |e 61400PK14017589X |k 0/60000/ |k 1/60000/61400/ |p 14 | ||
| 998 | |g 1028873905 |a Schnülle, Peter |m 1028873905:Schnülle, Peter |d 60000 |d 61400 |e 60000PS1028873905 |e 61400PS1028873905 |k 0/60000/ |k 1/60000/61400/ |p 13 | ||
| 998 | |g 124090273 |a Köppel, Hannes |m 124090273:Köppel, Hannes |d 60000 |d 61400 |e 60000PK124090273 |e 61400PK124090273 |k 0/60000/ |k 1/60000/61400/ |p 12 | ||
| 998 | |g 129092738 |a Lammert, Alexander |m 129092738:Lammert, Alexander |d 60000 |d 61400 |e 60000PL129092738 |e 61400PL129092738 |k 0/60000/ |k 1/60000/61400/ |p 11 | ||
| 998 | |g 1030179123 |a Schmitt, Claus P. |m 1030179123:Schmitt, Claus P. |d 910000 |d 910500 |e 910000PS1030179123 |e 910500PS1030179123 |k 0/910000/ |k 1/910000/910500/ |p 8 | ||
| 998 | |g 118132202 |a Peters, Verena |m 118132202:Peters, Verena |d 910000 |d 910500 |e 910000PP118132202 |e 910500PP118132202 |k 0/910000/ |k 1/910000/910500/ |p 7 | ||
| 998 | |g 1155321650 |a Qiu, Jiedong |m 1155321650:Qiu, Jiedong |d 60000 |d 61400 |e 60000PQ1155321650 |e 61400PQ1155321650 |k 0/60000/ |k 1/60000/61400/ |p 6 | ||
| 998 | |g 1155321103 |a Braun, Jana D. |m 1155321103:Braun, Jana D. |d 60000 |d 61400 |e 60000PB1155321103 |e 61400PB1155321103 |k 0/60000/ |k 1/60000/61400/ |p 3 | ||
| 999 | |a KXP-PPN157154383X |e 3004496321 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"157154383X","person":[{"role":"aut","family":"Albrecht","display":"Albrecht, Thomas","given":"Thomas"},{"family":"Braun","role":"aut","display":"Braun, Jana D.","given":"Jana D."},{"display":"Qiu, Jiedong","given":"Jiedong","role":"aut","family":"Qiu"},{"role":"aut","family":"Peters","display":"Peters, Verena","given":"Verena"},{"family":"Schmitt","role":"aut","display":"Schmitt, Claus P.","given":"Claus P."},{"role":"aut","family":"Lammert","display":"Lammert, Alexander","given":"Alexander"},{"display":"Köppel, Hannes","given":"Hannes","role":"aut","family":"Köppel"},{"display":"Schnülle, Peter","given":"Peter","family":"Schnülle","role":"aut"},{"role":"aut","family":"Krämer","given":"Bernhard","display":"Krämer, Bernhard"},{"given":"Benito A.","display":"Yard, Benito A.","family":"Yard","role":"aut"},{"role":"aut","family":"Hauske","given":"Sibylle J.","display":"Hauske, Sibylle J."}],"note":["Gesehen am 29.03.2018"],"language":["eng"],"name":{"displayForm":["Thomas Albrecht, Shiqi Zhang, Jana D. Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P. Schmitt, Jacob van den Born, Stephan J. L. Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K. Krämer, Benito A. Yard, and Sibylle J. Hauske"]},"relHost":[{"recId":"742225437","origin":[{"publisher":"Wiley ; Hindawi","dateIssuedDisp":"2024-","dateIssuedKey":"2024","publisherPlace":"[Hoboken, NJ] ; New York, NY [u.a.]"}],"id":{"eki":["742225437"],"issn":["2314-6753"],"doi":["10.1155/1485"],"zdb":["2711897-6"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of diabetes research","title_sort":"Journal of diabetes research"}],"pubHistory":["2013-"],"note":["Gesehen am 13.01.2025"],"part":{"text":"2017(2017) Artikel-Nummer 9506730, 11 Seiten","extent":"11","year":"2017","volume":"2017"},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes durationJournal of diabetes research"}],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"3 May 2017"}],"title":[{"title":"The CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration","title_sort":"CNDP1 (CTG)5 polymorphism is associated with biopsy-proven diabetic nephropathy, time on hemodialysis, and diabetes duration"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"11 S."}],"id":{"doi":["10.1155/2017/9506730"],"eki":["157154383X"]}} | ||
| SRT | |a ALBRECHTTHCNDP1CTG5P3201 | ||