Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists
Non-selective and subunit (GluN2B)-specific N-methyl-d-aspartate receptor (NMDAR) antagonists represent promising alternative antidepressant drugs with fast onset of the therapeutic action. The neuronal activation pattern induced by NMDAR antagonists is well characterized by c-Fos expression analysi...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2017
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| In: |
Neuropharmacology
Year: 2017, Volume: 112, Pages: 181-187 |
| ISSN: | 1873-7064 |
| DOI: | 10.1016/j.neuropharm.2016.03.023 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.neuropharm.2016.03.023 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0028390816300958 
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| Author Notes: | Ioana Inta, Emese Domonkos, Natascha Pfeiffer, Rolf Sprengel, Markus Bettendorf, Undine E. Lang, Dragos Inta, Peter Gass |
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| 520 | |a Non-selective and subunit (GluN2B)-specific N-methyl-d-aspartate receptor (NMDAR) antagonists represent promising alternative antidepressant drugs with fast onset of the therapeutic action. The neuronal activation pattern induced by NMDAR antagonists is well characterized by c-Fos expression analysis only in the adult rodent brain. In contrast, there is little information available regarding their effects during postnatal development. Here we performed a systematic c-Fos brain mapping of the non-selective NMDAR antagonist MK-801 and the GluN2B-specific antagonist Ro 25-6981 from postnatal day 16 (P16) to P40. We found significant regional differences with gender-specificity in the activation pattern compared to the adult. Surprisingly, in the hippocampus, MK-801 triggered at pre-pubertal stages (especially at P24) very strong c-Fos expression, followed by low levels after P30, the approximate time point of puberty onset in mice. The cortical distribution of MK-801-triggered c-Fos expression before puberty differed also substantially from the adult brain, showing high levels only in deep cortical layers at pre-pubertal stages. In comparison, the cortical activation induced by Ro 25-6981 diminished from high pre-pubertal levels and was in comparison with that triggered by MK-801 low in the hippocampus. These results reveal highly dynamic changes in the c-Fos activation pattern induced by NMDAR antagonists during puberty. This article is part of the Special Issue entitled ‘Ionotropic glutamate receptors’. | ||
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