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Clinical impact of rest dual-energy computed tomography myocardial perfusion in patients with coronary artery disease

Background/Aim: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. Materials and...

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Hauptverfasser: Baumann, Stefan (VerfasserIn) , Becher, Tobias (VerfasserIn) , Haubenreisser, Holger (VerfasserIn) , Vogler, Nils (VerfasserIn) , Borggrefe, Martin (VerfasserIn) , Schönberg, Stefan (VerfasserIn) , Akın, Ibrahim (VerfasserIn) , Henzler, Thomas (VerfasserIn) , Loßnitzer, Dirk (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November-December 2017
In: In vivo
Year: 2017, Jahrgang: 31, Heft: 6, Pages: 1153-1157
ISSN:1791-7549
DOI:10.21873/invivo.11182
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.21873/invivo.11182
Verlag, kostenfrei, Volltext: http://iv.iiarjournals.org/content/31/6/1153
Volltext
Verfasserangaben:Stefan Baumann, Marlon Rutsch, Tobias Becher, Philipp Kryeziu, Holger Haubenreisser, Nils Vogler, Celi Anne Schoenike, Martin Borggrefe, Stefan O. Schoenberg, Ibrahim Akin, Thomas Henzler and Dirk Lossnitzer
Beschreibung
Zusammenfassung:Background/Aim: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. Materials and Methods: Patients who had undergone coronary computed tomography angiography (cCTA), rest DECT-P and ICA were analyzed. Results: We evaluated 51 patients (62.7% males, mean age 51.6±12.8 years). Rest DECT-P identified perfusion defects in three (10.7%) of the 28 patients with cCTA negative for luminal stenosis and in 10 (43.5%) of the 23 patients with cCTA positive for luminal stenosis. In total, 21 patients underwent both cCTA and ICA, of which seven (33.3%) showed obstructive CAD. Rest DECT-P revealed false-negative results in four cases (19.1%) and false-positive results in six cases (28.6%). Conclusion: Adding rest DECT-P to cCTA has no incremental diagnostic value over cCTA alone, to exclude haemodynamically significant CAD. Therefore, a rest-stress-DECT-P protocol or a CT-based FFR calculation might be a promising concept to improve diagnostic accuracy in a real clinical setting.
Beschreibung:Gesehen am 04.04.2018
Beschreibung:Online Resource
ISSN:1791-7549
DOI:10.21873/invivo.11182

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