Impact of coronary heart disease on cognitive decline in Alzheimer’s disease: a prospective longitudinal cohort study in primary care
Background: Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. Aim: To determine whether CHD increases the speed of cognitive decline in Alzheimer’s disease, and to discuss the po...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2017
|
| In: |
The British journal of general practice
Year: 2017, Jahrgang: 67, Heft: 655, Pages: e111-e117 |
| ISSN: | 1478-5242 |
| DOI: | 10.3399/bjgp16X688813 |
| Online-Zugang: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.3399/bjgp16X688813 Verlag, teilw. kostenfrei, Volltext: http://bjgp.org.ezproxy.medma.uni-heidelberg.de/content/67/655/e111 
|
| Verfasserangaben: | Markus Bleckwenn, Luca Kleineidam, Michael Wagner, Frank Jessen, Siegfried Weyerer, Jochen Werle, Birgitt Wiese, Dagmar Lühmann, Tina Posselt, Hans-Helmut König, Christian Brettschneider, Edelgard Mösch, Dagmar Weeg, Angela Fuchs, Michael Pentzek, Tobias Luck, Steffi G. Riedel-Heller, Wolfgang Maier and Martin Scherer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1571702881 | ||
| 003 | DE-627 | ||
| 005 | 20230426124231.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180404s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3399/bjgp16X688813 |2 doi | |
| 035 | |a (DE-627)1571702881 | ||
| 035 | |a (DE-576)501702881 | ||
| 035 | |a (DE-599)BSZ501702881 | ||
| 035 | |a (OCoLC)1341001638 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bleckwenn, Markus |d 1976- |e VerfasserIn |0 (DE-588)128594993 |0 (DE-627)376263938 |0 (DE-576)297232797 |4 aut | |
| 245 | 1 | 0 | |a Impact of coronary heart disease on cognitive decline in Alzheimer’s disease |b a prospective longitudinal cohort study in primary care |c Markus Bleckwenn, Luca Kleineidam, Michael Wagner, Frank Jessen, Siegfried Weyerer, Jochen Werle, Birgitt Wiese, Dagmar Lühmann, Tina Posselt, Hans-Helmut König, Christian Brettschneider, Edelgard Mösch, Dagmar Weeg, Angela Fuchs, Michael Pentzek, Tobias Luck, Steffi G. Riedel-Heller, Wolfgang Maier and Martin Scherer |
| 264 | 1 | |c February 2017 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.04.2018 | ||
| 520 | |a Background: Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. Aim: To determine whether CHD increases the speed of cognitive decline in Alzheimer’s disease, and to discuss the potential for secondary cardiovascular prevention to modify this decline. Design and setting: Prospective multicentre cohort study in general practices in six cities in Germany. Method: Participants were patients with probable mild-to-moderate Alzheimer’s dementia or mixed dementia (n = 118; mean age 85.6 [±3.4] years, range 80-96 years). The authors assessed the presence of CHD according to the family physicians’ diagnosis. Cognitive performance was measured during home visits for up to 3 years in intervals of 6 months, using Mini Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB). The authors also recorded whether patients died in the observation period. Results: At baseline, 65 patients (55%) had CHD and/or a heart condition following a myocardial infarction. The presence of CHD accelerated cognitive decline (MMSE, P<0.05) by about 66%, and reduced cognitive-functional ability (CDR-SoB, P<0.05) by about 83%, but had no impact on survival. Conclusion: The study shows that CHD has a significant influence on cognitive decline in older patients with late-onset dementia. The dementia process might therefore be positively influenced by cardiovascular prevention, and this possible effect should be further investigated. | ||
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a cardiovascular diseases | |
| 650 | 4 | |a cardiovascular risk | |
| 650 | 4 | |a cognitive decline | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a family practice | |
| 650 | 4 | |a primary health care | |
| 700 | 1 | |a Weyerer, Siegfried |d 1947- |e VerfasserIn |0 (DE-588)109057597 |0 (DE-627)506001407 |0 (DE-576)289630843 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The British journal of general practice |d London : Royal College of General Practitioners, 1990 |g 67(2017), 655, Seite e111-e117 |h Online-Ressource |w (DE-627)359784259 |w (DE-600)2097982-4 |w (DE-576)120281325 |x 1478-5242 |7 nnas |a Impact of coronary heart disease on cognitive decline in Alzheimer’s disease a prospective longitudinal cohort study in primary care |
| 773 | 1 | 8 | |g volume:67 |g year:2017 |g number:655 |g pages:e111-e117 |g extent:7 |a Impact of coronary heart disease on cognitive decline in Alzheimer’s disease a prospective longitudinal cohort study in primary care |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3399/bjgp16X688813 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://bjgp.org.ezproxy.medma.uni-heidelberg.de/content/67/655/e111 |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180404 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 109057597 |a Weyerer, Siegfried |m 109057597:Weyerer, Siegfried |d 60000 |e 60000PW109057597 |k 0/60000/ |p 5 | ||
| 999 | |a KXP-PPN1571702881 |e 3004927497 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"pubHistory":["40.1990 -"],"titleAlt":[{"title":"BJGP"}],"part":{"volume":"67","text":"67(2017), 655, Seite e111-e117","extent":"7","year":"2017","issue":"655","pages":"e111-e117"},"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Impact of coronary heart disease on cognitive decline in Alzheimer’s disease a prospective longitudinal cohort study in primary careThe British journal of general practice","note":["Gesehen am 04.10.2018"],"language":["eng"],"recId":"359784259","title":[{"title":"The British journal of general practice","subtitle":"BJGP","title_sort":"British journal of general practice"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1990-","publisher":"Royal College of General Practitioners","dateIssuedKey":"1990","publisherPlace":"London"}],"id":{"issn":["1478-5242"],"eki":["359784259"],"zdb":["2097982-4"]}}],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Markus Bleckwenn, Luca Kleineidam, Michael Wagner, Frank Jessen, Siegfried Weyerer, Jochen Werle, Birgitt Wiese, Dagmar Lühmann, Tina Posselt, Hans-Helmut König, Christian Brettschneider, Edelgard Mösch, Dagmar Weeg, Angela Fuchs, Michael Pentzek, Tobias Luck, Steffi G. Riedel-Heller, Wolfgang Maier and Martin Scherer"]},"id":{"doi":["10.3399/bjgp16X688813"],"eki":["1571702881"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"February 2017"}],"language":["eng"],"recId":"1571702881","note":["Gesehen am 04.04.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Markus","family":"Bleckwenn","role":"aut","display":"Bleckwenn, Markus","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Weyerer, Siegfried","given":"Siegfried","family":"Weyerer"}],"title":[{"title_sort":"Impact of coronary heart disease on cognitive decline in Alzheimer’s disease","title":"Impact of coronary heart disease on cognitive decline in Alzheimer’s disease","subtitle":"a prospective longitudinal cohort study in primary care"}]} | ||
| SRT | |a BLECKWENNMIMPACTOFCO2017 | ||